ASSOCIATION OF microRNA137 GENE POLYMORPHISMS WITH AGE AT ONSET AND POSITIVE SYMPTOMS OF SCHIZOPHRENIA IN A HAN CHINESE POPULATION
ASSOCIATION OF microRNA137 GENE POLYMORPHISMS WITH AGE AT ONSET AND POSITIVE SYMPTOMS OF SCHIZOPHRENIA IN A HAN CHINESE POPULATION
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DOI：
10.2190/pm.47.2.f
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发表时间：
2014-02-01
影响因子：
2
通讯作者：
Lv, Luxian
中科院分区：
文献类型：
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作者：
Wang, Shuai;Li, Wenqiang;Lv, Luxian
目的：microRNA137(MiRNA137)调节与脑发育有关的几个基因的表达，最近的一项大基因组广泛关联研究揭示了miRNA137与精神分裂症之间可能的关联。方法：比较300例精神分裂症患者和300例健康对照的miRNA137宿主基因片段rs66642155和rs1625579A/C的等位基因变异情况。并对这些基因多态性与精神分裂症临床特征的相关性进行了检验。结果：患者组和对照组的基因频率和等位基因频率差异无统计学意义。然而，在患者中，野生型rs66642155携带者的发病年龄比突变携带者要晚得多。精神分裂症野生型rs66642155携带者阳性与阴性症状量表(PANSS)总分、五因子模型总分、妄想症状分均显著高于野生型精神分裂症携带者，而突变携带者的意志障碍症状评分显著高于野生型精神分裂症携带者。结论：miRNA137可能不是精神分裂症的重要易感基因，但在患者中，miRNA137的rs66642155等位基因变异可能影响患者的发病年龄和阳性症状的严重程度。
Objectives: MicroRNA137 (miRNA137) regulates several gene expressions involved in brain development, and a recent large genome wide association study (GWAS) revealed a possible association between miRNA137 and schizophrenia. Methods: The allelic variants of rs66642155, a variable number tandem repeat polymorphism, and the single nucleotide polymorphism rs1625579 A/C in the miRNA137 host gene fragment were compared between 300 schizophrenic patients and 300 healthy controls from the Han Chinese population. The association of these polymorphisms with clinical characteristics of schizophrenia was also tested. Results: Genotype and allele frequencies of these polymorphisms were not significantly different between patient and control populations. In patients, however, age at onset was much later in wild type rs66642155 carriers than in mutation carriers. Total positive score on the Positive and Negative Symptom Scale (PANSS), total five-factor model positive score, and the delusions symptom score were all significantly higher in wild type rs66642155 carriers with schizophrenia, while the disturbance of volition symptom score was significantly higher in the mutation carriers with schizophrenia. Conclusions: MiRNA137 may not be a significant susceptibility gene for schizophrenia, but in patients, rs66642155 allelic variant of miRNA137 appears to influence age at onset and the severity of positive symptoms.