Facile synthesis of covalent organic framework incorporated electrospun nanofiber and application to pipette tip solid phase extraction of sulfonamides in meat samples
Facile synthesis of covalent organic framework incorporated electrospun nanofiber and application to pipette tip solid phase extraction of sulfonamides in meat samples
复制标题
轻松合成包含电纺纳米纤维的共价有机框架，并将其应用于移液器吸头固相萃取肉类样品中的磺酰胺。
DOI：
10.1016/j.chroma.2018.11.039
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发表时间：
2019-01-07
影响因子：
4.1
通讯作者：
Wu, Chunhua
中科院分区：
文献类型：
--
作者：
Yan, Zhiming;Hu, Biqing;Wu, Chunhua
本文合成了共价有机骨架SNW-1/聚丙烯腈（SNW-1@PAN）复合吸附剂，并将其用作移液管尖端固相萃取（PT-SPE）吸附剂，用于肉类样品中5种磺胺类药物的预富集。通过水热合成SNW-1和共静电纺丝制备了SNW-1@PAN复合材料。静电纺丝三维网状结构在PT-SPE应用中既提供了低背压又提供了快速的传质，从而避免了直接将SNW-1装入PT-SPE柱中所引起的高背压和泄漏问题。采用SNW-1@PAN固相萃取柱对肉类样品中的水杨酸进行提取，并进行高效液相色谱分析。考察了不同工艺参数对萃取和解吸效率的影响，并对工艺参数进行了优化。在最佳条件下，水杨酸的线性范围为5-125 ng mL（-1），相关系数均大于0.998，检出限为1.7 ~ 2.7 ng mL（-1）。5种SA的5次重复浸提（每次50 ng/mL）的日间和日内精密度（RSD）在5.4- 9.2%范围内。通过分析猪肉和鸡肉样品中的SA，研究了该方法的适用性。5种水杨酸的加标回收率在86-111%之间，精密度良好，表明该方法可用于复杂真实的样品中水杨酸的测定。(C)2018 Elsevier B. V.版权所有。
In this work, covalent organic frameworks SNW-1 incorporated polyacrylonitrile (SNW-1@PAN) nanofiber was synthesized and used as pipette tip solid phase extraction (PT-SPE) adsorbent for pre-concentration of five sulfonamides (SAs) in meat samples. The SNW-1@PAN nanofiber was fabricated via two steps, including the hydrothermal synthesis of SNW-1 and co-electrospinning of the SNW-1 /PAN mixture. The three dimensional networks of electrospun nanofiber provide both low backpressure and rapid mass transfer in PT-SPE application, thus preventing the problems of high backpressure and leakage caused by directly packing SNW-1 into PT-SPE cartridge. The SNW-l@PAN nanofiber packed PT-SPE cartridge was used to extract SAs in meat samples followed by high performance liquid chromatography (HPLC). The effects of different parameters influencing the extraction and desorption efficiency were intensively investigated and optimized. Under the optimum conditions, the linear ranges of SAs were in the range of 5-125 ng mL(-1) with correlation coefficients above 0.998, and the limits of detection of the five SAs ranged from 1.7 to 2.7 ngmL(-1) . The interday and intraday precision (RSD) for five replicate extractions of the five SAs (50 ng mL(-1) for each) was in the range of 5.4-9.2%. The applicability of the proposed method was examined by analyzing the SAs in the pork and chicken samples. The recoveries of the five SAs varied in the range of 86-111% with good precision, showing the good capability of the proposed method for the determination of SAs in the complicated real samples. (C) 2018 Elsevier B.V. All rights reserved.