Clinical manifestation of norovirus gastroenteritis in health care settings
Clinical manifestation of norovirus gastroenteritis in health care settings
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DOI：
10.1086/421948
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发表时间：
2004-08-01
影响因子：
11.8
通讯作者：
Brown, DWG
中科院分区：
文献类型：
--
作者：
Lopman, BA;Reacher, MH;Brown, DWG
人们普遍认为诺如病毒会在其他方面健康的成年人中引起相对轻微的短期胃肠炎。然而，医疗机构中的疫情爆发很常见，并影响到弱势群体。 2002年至2003年期间，对英国埃文县总共4家大医院、11家社区医院和135家疗养院进行了胃肠炎疫情的前瞻性监测。 482 名医院工作人员、166 名疗养院工作人员和 266 名疗养院居民的诺如病毒胃肠炎中位持续时间为 2 天，其中 75% 在 3 天内完全康复。 730 名住院患者的诺如病毒胃肠炎中位持续时间为 3 天（75% 的患者在 5 天内完全康复），明显长于所有其他组 (P < .001)。因此，住院患者的感染可能比整个社区其他群体的感染更为严重。在采取措施防止在医院环境中传播时，应考虑急性疾病持续时间的增加。
Noroviruses are generally believed to cause relatively mild gastroenteritis of short duration in otherwise healthy adults. However, outbreaks in health care settings are common and affect vulnerable populations. During 2002-2003, a total of 4 major hospitals, 11 community hospitals, and 135 nursing homes in the county of Avon, England, were prospectively monitored for outbreaks of gastroenteritis. For 482 hospital staff, 166 nursing home staff, and 266 nursing home residents, the median duration of norovirus gastroenteritis was 2 days, with 75% achieving complete recovery within 3 days. The median duration of norovirus gastroenteritis for 730 hospital patients was 3 days (75% of the patients achieved complete recovery within 5 days), which was significantly longer than that for all other groups (P < .001). Therefore, infection in hospitalized persons may be more severe than that in other groups in the community at large. This increased duration of acute illness should be considered when implementing measures to prevent transmission in hospital settings.