Transition from acute kidney injury to chronic kidney disease: a single-centre cohort study
Transition from acute kidney injury to chronic kidney disease: a single-centre cohort study
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DOI：
10.1007/s10157-018-1571-5
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发表时间：
2018-12-01
影响因子：
2.3
通讯作者：
Okuhara, Yoshiyasu
中科院分区：
文献类型：
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作者：
Hatakeyama, Yutaka;Horino, Taro;Okuhara, Yoshiyasu
背景急性肾损伤（阿基）的发病率呈上升趋势。阿基目前被认为是慢性肾病（CKD）的诱导物，这被称为AKI-CKD转变。本研究旨在评估与阿基事件相关的估计肾小球滤过率（eGFR）的下降率，在个人与不预先存在CKD.MethodsInpatients年龄在18- 80岁的回顾性入组。根据肾脏疾病改善总体结局（KDIGO）标准，使用血清肌酐水平诊断阿基。根据阿基事件前后的eGFR，将有AKI事件史的患者分为4组。在每组中，将阿基事件后的eGFR水平与阿基事件前的eGFR水平进行比较。根据基础疾病、药物和手术史的临床背景，患者进一步分为8组。ResultsWe分析了9651例阿基患者的数据。毫不奇怪，我们发现第一次阿基事件期间的eGFR水平显著低于每组事件前的水平。此外，第一次阿基事件后的eGFR水平显著低于第一次阿基事件前的水平，第二次阿基事件后的eGFR水平显著低于第一次阿基事件后的水平。这些趋势是相似的，在每个组，无论临床background.ConclusionsOur研究表明，阿基事件可以导致肾功能下降，随着更多的阿基事件发生，这种下降的加速。
BackgroundThe incidence of acute kidney injury (AKI) is increasing. AKI is currently recognised as an inducer of chronic kidney disease (CKD) and this is known as the AKI-CKD transition'. This study aimed to evaluate the rate of decline in estimated glomerular filtration rate (eGFR) associated with AKI events in individuals with and without pre-existing CKD.MethodsInpatients aged 18-80years were retrospectively enrolled. AKI was diagnosed according to the kidney disease improving global outcomes (KDIGO) criteria using serum creatinine levels. Patients with a history of AKI events were divided into four groups according to eGFR before and after the AKI events. In each group, the eGFR levels after an AKI event were compared to those before the AKI event. Patients were further divided into eight groups according to clinical background based on underlying diseases, medications, and surgical history.ResultsWe analysed data from 9651 patients with AKI. Not surprisingly, we found that eGFR levels during the first AKI event were significantly lower than levels before the event in each group. Furthermore, eGFR levels after the first AKI event were significantly lower than those before the first AKI event, and the eGFR levels after the second AKI event were significantly lower than those after the first AKI event. These trends were similar in each group irrespective of clinical background.ConclusionsOur study revealed that AKI events can cause a decline in kidney function and, as more AKI events occur, acceleration of this decline.