Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes
Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes
复制标题
血清维生素 D 与体重和肝酶正常的中国男性非酒精性脂肪肝相关
DOI：
10.1038/aps.2014.48
复制
发表时间：
2014-09-01
影响因子：
8.2
通讯作者：
Jia, Wei-ping
中科院分区：
文献类型：
--
作者：
Hao, Ya-ping;Ma, Xiao-jing;Jia, Wei-ping
目的：考虑维生素D缺乏是异位脂肪沉积的危险因素，探讨体重指数(BMI)和肝功能酶标记物正常的中国男性血清25-羟基维生素D3[25(OH)D3]水平与非酒精性脂肪性肝病(NAFLD)的关系。腹部超声诊断NAFLD，计算脂肪肝指数(FLI)量化肝脏脂肪变性。结果：在整个研究人群中，25(OH)D3的平均水平为15.32±5.77 ng/mL。非酒精性脂肪肝患者(n=438)与酒精性脂肪肝患者(n=76)的血清25(OH)D3水平比较，后者显著低于非酒精性脂肪肝患者(15.65±5.89 ng/mLvs13.46±4.65 ng/mL，P=0.002)。此外，在调整年龄和体重指数后，血清25(OH)D3水平与肝功能指数显著相关(r=−0.108，P=0.014)。Logistic回归分析显示，血清25(OH)D3水平与非酒精性脂肪肝独立相关(OR：0.937，95%CI：0.884~0.993，P=0.028)。逐步回归分析显示血清25(OH)D3水平与脂肪肝的发生、发展呈负相关(β=−为0.055，P=0.040)。结论：即使在体脂正常的人群中，血清25(OH)D3水平也与脂肪肝的发生、发展呈负相关，提示维生素D水平降低在脂肪肝的发生发展中可能起重要作用。
Aim:Considering the characterization of vitamin D deficiency as a risk factor of ectopic fat deposition, the association of serum 25-hydroxy vitamin D 3 [25 (OH) D 3] levels with non-alcoholic fatty liver disease (NAFLD) was evaluated in Chinese men with normal body mass index (BMI) and enzyme markers of liver function.Methods:A total of 514 participants (22 to 79 years old) with normal BMI and liver enzymes were identified for analysis. Abdominal ultrasound was performed to diagnose NAFLD, and the fatty liver index (FLI) was calculated to quantify liver steatosis. Serum 25 (OH) D 3 levels were determined by an electrochemiluminescence immunoassay.Results:Among the entire study population, the mean levels of serum 25 (OH) D 3 were 15.32±5.77 ng/mL. However, when serum 25 (OH) D 3 levels were compared between non-NAFLD subjects (n= 438) and NAFLD subjects (n= 76), the latter showed significantly lower levels (15.65±5.89 ng/mL vs 13.46±4.65 ng/mL, P= 0.002). In addition, serum 25 (OH) D 3 levels were found to be significantly correlated with FLI after adjustment for age and BMI (r=− 0.108, P= 0.014). Logistic regression showed that serum 25 (OH) D 3 levels were independently correlated with NAFLD (OR: 0.937, 95% CI: 0.884–0.993, P= 0.028). Furthermore, stepwise regression analysis revealed that serum 25 (OH) D 3 levels were inversely associated with FLI (β=− 0.055, P= 0.040).Conclusion:The present study demonstrated that serum 25 (OH) D 3 levels were inversely associated with NAFLD, even in subjects with normal total body fat, suggesting a potential role of lower levels of vitamin D in the occurrence and development of NAFLD.