ANTIANXIETY PROPERTIES OF THE ANGIOTENSIN-II ANTAGONIST, DUP 753, IN THE RAT USING THE ELEVATED PLUS-MAZE
ANTIANXIETY PROPERTIES OF THE ANGIOTENSIN-II ANTAGONIST, DUP 753, IN THE RAT USING THE ELEVATED PLUS-MAZE
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DOI：
10.1097/00001756-199210000-00026
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发表时间：
1992-10-01
期刊：
影响因子：
1.7
通讯作者：
HALLAM, C
中科院分区：
文献类型：
--
作者：
KAISER, FC;PALMER, GC;HALLAM, C
血管紧张素II受体拮抗剂，DUP 753（氯沙坦），比较了安定的抗焦虑性能在大鼠使用高架十字迷宫。口服地西泮（5 mg kg-1）导致大鼠进入迷宫开放臂的次数显著增加，在开放臂中花费的时间增加，在封闭臂中花费的时间减少。口服DUP 753同样导致进入开放臂的数量显著增加（在0.0001、0.001、0.01和0.1 mg kg-1下具有活性），在开放臂上花费的时间增加（活性在0.0001-0.01 mg kg-1）和在闭合臂中花费的时间减少（活性在0.0001、0.01和0.1 mg kg-1）。较大（1.0 mg kg-1）或较小（0.00001 mg kg-1）剂量的DUP 753无活性。
THE angiotensin II receptor antagonist, DUP 753 (Losartan), was compared with diazepam for antianxiety properties in the rat using the elevated plus-maze. Oral diazepam (5 mg kg-1) resulted in a significantly greater number of entries of rats into the open arms of the maze, an increase in time spent in the open arms and a decreased time spent in the closed arms. Oral doses of DUP 753 likewise resulted in significantly greater numbers of entries into the open arms (active at 0.0001, 0.001, 0.01 and 0.1 mg kg-1), increased time spent on the open arms (active at 0.0001-0.01 mg kg-1) and a decreased time spent in the closed arms (active at 0.0001, 0.01 and 0.1 mg kg-1). Larger (1.0 mg kg-1) or smaller (0.00001 mg kg-1) doses of DUP 753 were not active.