Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier
Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier
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DOI：
10.1006/bbrc.1996.0980
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发表时间：
1996-07-05
影响因子：
3.1
通讯作者：
Muramatsu, T
中科院分区：
文献类型：
--
作者：
Igakura, T;Kadomatsu, K;Muramatsu, T
Basigin是属于免疫球蛋白超家族的跨膜糖蛋白。利用缺失basigin基因（Bsg）的敲除小鼠，我们分析了basigin在缺失该基因[Bsg（-/-）]的成年小鼠中的功能。尽管对basigin（也称为HT 7和神经皮素）的定位的组织化学研究强烈表明其参与血脑屏障的功能，但basigin敲除小鼠在血脑屏障的功能方面与野生型小鼠仅显示出很小的差异（如果有的话）。Bsg（-/-）小鼠的淋巴细胞对混合淋巴细胞反应的促有丝分裂反应更强。最后，Bsg（-/-）小鼠反复访问浸渍有乙酸或异嗪的滤纸，表明其对气味的接收或行为异常。
Basigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of basigin in adult mice lacking the gene [Bsg (-/-)]. Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood-brain barrier, basigin knockout mice showed only a little difference, if any, to wild-type mice in the function of the blood brain-barrier. The mitogenic response of lymphocytes upon mixed lymphocyte reaction was greater in Bsg (-/-) mice. Finally, Bsg (-/-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it. (C) 1996 Academic Press, Inc.