Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer
Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer
复制标题
B 型 Eph 和 ephrin 基因的过度表达与人类胰腺癌的进展和疼痛相关
DOI：
10.3892/ol.2012.650
复制
发表时间：
2012-06-01
期刊：
影响因子：
2.9
通讯作者：
Yang, Yinxue
中科院分区：
文献类型：
--
作者：
Lu, Zhenhui;Zhang, Yong;Yang, Yinxue
B 型促红细胞生成素生成肝细胞 (EphB) 受体及其肝配蛋白配体与许多恶性肿瘤的攻击行为和不良预后相关。本研究的目的是确定这些基因的异常表达与人类胰腺癌预后之间的关联。使用实时定量逆转录 PCR 在 46 例人类原发性胰腺癌中测定了 EphB 和肝配蛋白配体的表达。在超过 44% (20/46) 的胰腺癌样本中观察到 EphB2 过度表达和肝配蛋白-B2 mRNA 适度过度表达。 EphB2 和 ephrin-B2 的过度表达（>上四分位）与腹部和/或背痛显着相关。多变量分析确定 EphB2 的过度表达是无病生存和总生存的独立预后因素（P
B-type erythropoietin-producing hepatocellular (EphB) receptors and their ephrin ligands are associated with aggressive behavior and poor prognosis in a number of malignancies. The aim of this study was to determine the association between the aberrant expression of these genes and prognosis in human pancreatic cancer. The expression of EphB and the ephrin ligands was determined using real-time quantitative reverse transcription PCR in 46 human primary pancreatic cancers. Overexpression of EphB2 and a more modest overexpression of ephrin-B2 mRNA were observed in more than 44% (20/46) of the pancreatic cancer specimens examined. Overexpression (>upper quartile) of EphB2 and ephrin-B2 was markedly associated with abdominal and/or back pain. Multivariate analysis identified the overexpression of EphB2 as an independent prognostic factor for disease-free and overall survival (both P