Protective role of IL-18 in host defenses against group B Streptococcus
Protective role of IL-18 in host defenses against group B Streptococcus
复制标题
DOI：
10.1007/s10096-021-04299-y
复制
发表时间：
2021-07-04
影响因子：
4.5
通讯作者：
Biondo, C.
中科院分区：
文献类型：
--
作者：
Mancuso, G.;Midiri, A.;Biondo, C.
本研究的目的是调查 IL-18（IL-1 家族成员）在 B 族链球菌 (GBS) 感染中的作用。在 GBS 感染的新生儿和成人模型中，IL-18 缺陷动物比 WT 动物更容易受到感染。 IL18 的缺乏与细菌刺激后 IFN-γ 水平的显着降低有关，但在将 PMN 募集到 GBS 感染部位方面并没有发挥显着作用。总的来说，我们的数据记录了 IL-18 信号传导在增强宿主针对 GBS 感染的免疫反应方面的基本功能。
The aim of this study was to investigate the role of IL-18, a member of the IL-1 family, in group B Streptococcus (GBS) infection. Both in a neonatal and adult model of GBS infection, IL-18-deficient animals were significantly more susceptible to infection than WT animals. The lack of IL18 was associated with a marked reduction in IFN-gamma-levels after bacterial stimulation but did not play a significant role in the recruitment of PMN to sites of GBS infection. Collectively, our data document a fundamental function of IL-18 signaling in boosting the host immune responses against GBS infection.