Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension
Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension
复制标题
DOI：
10.1038/ki.2008.397
复制
发表时间：
2008-11-01
影响因子：
19.6
通讯作者：
Schrier, Robert W.
中科院分区：
文献类型：
--
作者：
Cadnapaphornchai, Melissa A.;McFann, Kim;Schrier, Robert W.
常染色体显性多囊肾病（ADPKD）是一种常见的遗传性疾病，可以在子宫内诊断。我们的目的是评估儿童ADPKD的症状，包括左心室质量指数（LVMI），肾容量，肾功能和微量白蛋白尿与收缩压和舒张压的关系。将85名儿童按血压分为三个队列：高血压（第95百分位数及以上）、临界高血压（第75- 95百分位数）和血压正常（第75百分位数及以下）。两组之间在性别、年龄、身高、肾功能或微量白蛋白尿方面没有差异。高血压组和临界高血压组的LVMI均显著高于正常血压组，而高血压组和临界高血压组之间无显著差异。在所有受试者中，肾脏体积与收缩压和舒张压之间存在显著相关性。高血压儿童的肾脏体积明显大于临界高血压组，而正常血压组和临界高血压组之间无显著差异。这些结果表明，在ADPKD和临界高血压儿童中，LVMI增加可能早于肾脏体积增加，这表明需要密切监测这些儿童的心脏状态。
Autosomal dominant polycystic kidney disease ( ADPKD) is a common hereditary condition that may be diagnosed in utero. Our goal was to evaluate symptoms of ADPKD in children, including left ventricular mass index (LVMI), renal volume, renal function and microalbuminuria in relation to systolic and diastolic blood pressure. Eighty-five children were stratified by blood pressure into three cohorts: hypertensive (95th percentile and over), borderline hypertensive (75-95th percentile) and normotensive (75th percentile and below). There were no differences in gender, age, height, renal function, or microalbuminuria between the groups. Both the hypertensive and borderline hypertensive children had a significantly higher LVMI than normotensive children, with no significant difference between hypertensive and borderline hypertensive groups. There was a significant correlation between renal volume and both systolic and diastolic blood pressures in all subjects. Renal volume in hypertensive children was significantly larger than in the borderline hypertensive group, with no significant difference between normotensive and borderline hypertensive groups. These findings show that an increase in LVMI may be detected earlier than an increase in renal volume in children with ADPKD and borderline hypertension, suggesting that close monitoring of cardiac status is indicated in these children.