A deficit in discriminating gaze direction in a case with right superior temporal gyrus lesion
A deficit in discriminating gaze direction in a case with right superior temporal gyrus lesion
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DOI：
10.1016/j.neuropsychologia.2005.05.018
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Kashima, H
中科院分区：
文献类型：
--
作者：
Akiyama, T;Kato, M;Kashima, H
颞上沟区(STS)被公认为是探测和辨别凝视的重要区域。局限于这一区域的病变在人类中相当罕见，因此这项研究主要依赖于动物研究和正常人类的功能神经成像。我们报告一个罕见的病例，一位54岁的日本女性，可能患有先天性S畸形，在脑出血后，发现病变几乎完全局限于整个右侧颞叶上回。在亚急性期，患者表现出左侧空间忽视的证据，并逐渐恢复。在慢性期，她在获得眼神交流方面表现出令人费解的困难。我们结合常规的神经心理学评估，对她的凝视认知能力进行了实验评估。她在神经心理测试中的表现表明，她在智力、记忆力或语言技能方面没有妥协，几乎完全从忽视中恢复过来。在凝视认知实验中，她反复被证明将左侧视线视为直视，并在较小程度上将直视视线视为右侧视线。我们认为，STG在检测凝视方面的功能，以及它从早期视觉区域接收到的方向性信息，在受损时可能与检测反向凝视的缺陷有关。我们首次证明了STG的单个限制性损伤会导致受害者本人的凝视加工缺陷和同时出现的异常凝视行为，这暗示了STG内的一种机制，即他人的凝视和自我的凝视之间的界面。(C)2005爱思唯尔有限公司。保留所有权利。
The superior temporal sulcus (STS) region is well recognized as being heavily involved in detecting and discriminating gaze. Lesions confined to this area are quite rare in humans, and so the research has mainly depended on animal studies and functional neuroimaging in normal human subjects. We report one such rare case, a 54-year-old Japanese female with a possible congenital s anomaly who, after a cerebral hemorrhage, demonstrated a lesion almost completely confined to the entire right superior temporal gyrus (STG). In the subacute phase, the patient showed evidence of left hemispatial neglect, from which she gradually recovered. In the chronic phase, she showed a puzzling difficulty in obtaining eye-contact. We have conducted, in conjunction with conventional neuropsychological evaluations, experimental assessment of her ability in gaze cognition. Her performance on neuropsychological testing demonstrated no compromise in intellect, memory, or language skills, and a close-to-full recovery from neglect. On gaze cognition experiments, she was repeatedly shown to perceive left gaze as straight, and to a lesser degree, straight gaze as right. We suggest that the function of the STG in detecting gaze, together with the directional information it receives from earlier visual areas, may be associated, when damaged, with this deficit in detecting contra-directional gaze. We have demonstrated for the first time that a single circumscribed lesion to the STG results in both gaze processing deficit and concurrent aberrant gaze behavior of the victim herself, implicating a mechanism within the STG as an interface between gaze of others and gaze of self. (c) 2005 Elsevier Ltd. All rights reserved.