Quantification of Cerebral Volumes on MRI 6 Months After Aneurysmal Subarachnoid Hemorrhage
Quantification of Cerebral Volumes on MRI 6 Months After Aneurysmal Subarachnoid Hemorrhage
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DOI：
10.1161/strokeaha.112.669184
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发表时间：
2012-10-01
期刊：
影响因子：
8.3
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
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作者：
de Bresser, Jeroen;Vincken, Koen L.;Biessels, Geert Jan
背景与目的：mri可用于评估动脉瘤性蛛网膜下腔出血后脑结构损伤。我们调整、验证并应用基于k近邻的分割来量化动脉瘤性蛛网膜下腔出血后6个月的MRI脑体积。方法：经过调优后，用人工分割方法对基于k近邻的分割方法进行精度评估。接下来，将55名患者的幕上脑实质、外周脑脊液和侧脑室体积与25名年龄和性别匹配的对照组进行比较，并与临床结果（改良Rankin量表）相关。结果基于k近邻的分割结果与人工分割结果吻合较好。与对照组相比，患者侧脑室容积较大（差异：对数转换值0.54;95% CI, 0.33-0.75），外周脑脊液体积较小（-26 mL, 95% CI， -40至-11），脑实质容积相似（2 mL, 95% CI， -10至15）。在患者中，脑实质（中位分裂；OR, 38.8; 95% CI, 4.6 -329.0）和心室容积（7.4;95% CI, 1.6-33.5）与功能预后相关。结论基于-k近邻的脑容量分割能准确测量动脉瘤性蛛网膜下腔出血后的脑容量。在这项体积测定技术的原理验证研究中，我们证明了相对于对照组的体积变化，这与功能结果相关。(中风。2012;43:2782 - 2784)。
Background and Purpose-MRI can be used to assess structural damage to the brain after aneurysmal subarachnoid hemorrhage. We tuned, validated, and applied k-Nearest Neighbor-based segmentation to quantify cerebral volumes on MRI 6 months after aneurysmal subarachnoid hemorrhage.Methods-After tuning, the accuracy of k-Nearest Neighbor-based segmentation was assessed with manual segmentations. Next, supratentorial cerebral parenchymal, peripheral cerebrospinal fluid, and lateral ventricular volumes of 55 patients were compared with those of 25 age-and sex-matched control subjects and related to clinical outcome (modified Rankin Scale).Results-k-Nearest Neighbor-based segmentation showed good agreement with manual segmentations. Compared with control subjects, patients had a larger lateral ventricular volume (difference: log-transformed values 0.54; 95% CI, 0.33-0.75), smaller peripheral cerebrospinal fluid volume (-26 mL; 95% CI, -40 to -11), and similar cerebral parenchymal volume (2 mL; 95% CI, -10 to 15). In patients, parenchymal (median split; OR, 38.8; 95% CI, 4.6 -329.0) and ventricular volumes (7.4; 95% CI, 1.6-33.5) correlated with functional outcome.Conclusions-k-Nearest Neighbor-based segmentation provides accurate cerebral volume measurements after aneurysmal subarachnoid hemorrhage. In this proof-of-principle study of this volumetric technique, we demonstrated volume changes relative to controls, which correlated with functional outcome. (Stroke. 2012;43:2782-2784.)