Variable-temperature and variable-pressure studies of small- molecule organic crystals
Variable-temperature and variable-pressure studies of small- molecule organic crystals
复制标题
小分子有机晶体的变温变压研究
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
E. Burgina
中科院分区：
文献类型：
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作者：
E. Boldyreva;T. Drebushchak;T. Shakhtshneider;H. Sowa;H. Ahsbahs;S. Goryainov;S. N. Ivashevskaya;E. N. Kolesnik;V. Drebushchak;E. Burgina
Several examples of the comparative variable-temperature and variable-pressure studies of the small-molecule organic crystals are discussed. Selected systems represent the crystals with non- spherical flexible molecules / molecular fragments and with different types of intermolecular interactions, ranging from van der Waals interactions to hydrogen bonds of various types (OH…O, NH…OH, NH…O=C). A special attention is payed to the studies of solid drugs (polymorphs of paracetamol), amino acids (polymorphs of glycine, L-serine, D,L-serine), and dipeptides (glycilglycine and glycilglycine hydrate) by structural, spectroscopic and calorimetric techniques. The anisotropy of structural distortion within the range of stability of the same phase, as well as the phase transitions induced by changes in temperature or pressure are discussed.
