Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
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DOI：
10.1016/j.neuroimage.2009.06.079
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发表时间：
2009-11-01
期刊：
影响因子：
5.7
通讯作者：
Hinz, Rainer
中科院分区：
文献类型：
--
作者：
Edison, Paul;Brooks, David J.;Hinz, Rainer
匹兹堡化合物B或[C-11] PI B是一种淀粉样蛋白成像剂，其在患有阿尔茨海默病（AD）的受试者和对照者之间显示出明显的区别。然而，在其他形式的痴呆如路易体痴呆（DLB）中观察到的信号差异较小，轻度认知障碍（MCI）受试者和一些健康的老年正常人可能显示中等水平的[C-11]PIB结合。小脑是AD [C-11]PIB研究中非特异性示踪剂摄取的常用参考区域，在朊病毒疾病或单基因型AD中可能无效。本工作的目的是：1-比较使用血浆输入函数生成组织中[C-11]PIB保留的参数图的方法在区分AD受试者和对照者的能力方面的差异，以及2-估计AD受试者的重测重现性。12例AD受试者（其中5例在6周内进行了重复扫描）和10例对照受试者进行了90分钟[C-11]PIB动态PET扫描，并测量了动脉血浆输入功能。通过可逆结合（Logan图）、不可逆结合（Patlak图）和光谱分析的图形分析生成参数图。使用Student t检验计算组间差异，并使用p值进行不同方法之间的比较。通过组内相关系数（ICC）评估生殖能力。我们发现，脉冲响应函数的75分钟值显示出最佳的组分化，并具有比Logan和频谱分析生成的分布图的体积更高的ICC。[C-11]PIB结合的Patlak分析重现性最差。(C)2009 Elsevier Inc. All rights reserved.
Pittsburgh compound B or [C-11]PIB is an amyloid imaging agent which shows a clear differentiation between subjects with Alzheimer's disease (AD) and controls. However the observed signal difference in other forms of dementia such as dementia with Lewy bodies (DLB) is smaller, and mild cognitively impaired (MCI) subjects and some healthy elderly normals may show intermediate levels of [C-11]PIB binding. The cerebellum, a commonly used reference region for non-specific tracer uptake in [C-11]PIB studies in AD may not be valid in Prion disorders or monogenic forms of AD. The aim of this work was to: 1-compare methods for generating parametric maps of [C-11]PIB retention in tissue using a plasma input function in respect of their ability to discriminate between AD subjects and controls and 2-estimate the test-retest reproducibility in AD subjects. 12 AD subjects (5 of which underwent a repeat scan within 6 weeks) and 10 control subjects had 90 minute [C-11]PIB dynamic PET scans, and arterial plasma input functions were measured. Parametric maps were generated with graphical analysis of reversible binding (Logan plot), irreversible binding (Patlak plot), and spectral analysis. Between group differentiation was calculated using Student's t-test and comparisons between different methods were made using p values. Reproducibility was assessed by intraclass correlation coefficients (ICC). We found that the 75 min value of the impulse response function showed the best group differentiation and had a higher ICC than volume of distribution maps generated from Logan and spectral analysis. Patlak analysis of [C-11]PIB binding was the least reproducible. (C) 2009 Elsevier Inc. All rights reserved.