Plastic bronchitis and the role of bronchoscopy in the acute chest syndrome of sickle cell disease
Plastic bronchitis and the role of bronchoscopy in the acute chest syndrome of sickle cell disease
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DOI：
10.1378/chest.120.2.608
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发表时间：
2001-08-01
期刊：
影响因子：
9.6
通讯作者：
Cooper, DM
中科院分区：
文献类型：
--
作者：
Moser, C;Nussbaum, E;Cooper, DM
研究目的：回顾镰状细胞病（SCD）急性胸部综合征（ACS）期间可塑性支气管炎患者的患病率、临床特征和支气管镜检查的作用。设计：8年临床经验回顾。设置：三级转诊儿童医院。患者：26名儿科住院患者，29次ACS发作，需要诊断性支气管镜检查。结果：在接受支气管镜检查的ACS儿科住院患者中，29例中有21例（72%）诊断为可塑性支气管炎。有与无可塑性支气管炎患者的临床特征无差异。支气管镜检查是一个重要的诊断工具，但其治疗效益是doubted.Conclusions：这是第一次报告的发病率与急性冠脉综合征的SCD患者的可塑性支气管炎。在我们的患者人群中，发现这种情况很常见。诊断性支气管镜检查的作用是必不可少的。需要进行一项大系列、多中心研究，以确定支气管镜检查和BAL在目前实施的支持治疗中是否有益。
Study objectives: To review the prevalence, clinical features, and role of bronchoscopy in patients with plastic bronchitis during the acute chest syndrome (ACS) of sickle cell disease (SCD).Design: Eight-year review of clinical experience.Setting: Tertiary referral children's hospital.Patients: Twenty-six pediatric inpatients with 29 ACS episodes requiring diagnostic bronchoscopy.Results: Of the pediatric inpatients with ACS who underwent bronchoscopy, plastic bronchitis was diagnosed in 21 of 29 episodes (72%). There was no difference in clinical features between the patients with and without plastic bronchitis. Bronchoscopy was an essential diagnostic tool, but its therapeutic benefits were doubtful.Conclusions: This is the first report of the prevalence of plastic bronchitis in patients with ACS of SCD. In our patient population, this condition was found to be common. The role of diagnostic bronchoscopy is essential. A large series, multicenter study is required to determine whether bronchoscopy and BAL are therapeutically beneficial when added to currently practiced supportive care.