T(reg) stability: to be or not to be.
T(reg) stability: to be or not to be.
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DOI：
10.1016/j.coi.2015.12.009
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发表时间：
2016-04
影响因子：
7
通讯作者：
Vignali DA
中科院分区：
文献类型：
--
作者：
Overacre AE;Vignali DA
调节性T细胞(Treg)的稳定性主要由转录因子Forkhead box P3(Foxp3)的维持表达决定。然而，Treg可以在维持Foxp3表达的同时表现出不稳定，这需要重新检查Treg稳定性的定义。最近的工作表明，除了Foxp3的表达外，Tregs的建立和稳定还受到许多机制的影响，如表观遗传修饰、Foxo1/3a定位、Eos的表达以及通过Neuropilin-1的信号转导。其他研究可能有助于确定在癌症中破坏Treg稳定性的方法，或在移植、自身免疫或炎症性疾病中增强Treg稳定性的方法，因此具有实质性的治疗作用。在这篇综述中，我们将讨论Treg稳定性是如何定义的，以及用来维持稳定性的机制。
Regulatory T cell (Treg) stability has been primarily determined by the maintained expression of the transcription factor Forkhead box P3 (Foxp3). However, Tregs can exhibit instability while maintaining Foxp3 expression, requiring a re-examination of what defines Treg stability. Recent work suggests that the establishment and stability of Tregs is mediated by a number of mechanisms besides Foxp3 expression, such as epigenetic modifications, Foxo1/3a localization, expression of Eos and signaling via Neuropilin-1. Additional studies may help to define approaches that can undermine Treg stability in cancer or enhance Treg stability in transplantation, autoimmune or inflammatory diseases and therefore have substantial therapeutic utility. In this review, we will discuss how Treg stability is defined and the mechanisms utilized to maintain stability.