PET imaging of nobiletin based on a practical total synthesis
PET imaging of nobiletin based on a practical total synthesis
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DOI：
10.1039/c0cc04936k
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Kan, Toshiyuki
中科院分区：
文献类型：
--
作者：
Asakawa, Tomohiro;Hiza, Aiki;Kan, Toshiyuki
利用我们的新的黄酮合成方法，完成了一种多甲氧基化柑橘黄酮--川陈皮素的实际合成。通过选择性去甲基化和C-11原子的快速掺入来标记合成的Nobiliprazine。正电子发射断层扫描图像成功地可视化了大脑分布，这可能为阿尔茨海默病的治疗提供治疗益处。
A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of C-11 atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.