Patterns of exercise across the cancer trajectory in brain tumor patients
Patterns of exercise across the cancer trajectory in brain tumor patients
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DOI：
10.1002/cncr.21858
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发表时间：
2006-05-15
期刊：
影响因子：
6.2
通讯作者：
Reardon, DA
中科院分区：
文献类型：
--
作者：
Jones, LW;Guill, B;Reardon, DA
背景运动可能是一种支持性干预，可以补充现有的神经肿瘤治疗，并解决脑肿瘤患者治疗引起的多种衰弱副作用。鉴于证据有限，作者进行了一项调查，以检查脑肿瘤患者的运动模式在整个癌症分类。采用横断面设计，386名在杜克大学脑肿瘤中心接受治疗的脑肿瘤患者被发送了一份问卷，评估诊断前、辅助治疗期间和治疗完成后自我报告的运动行为。缓解率为28%（383例患者中的106例）。描述性分析表明，分别有42%、38%和41%的参与者在诊断前、治疗期间和辅助治疗完成后符合国家运动处方指南。重复测量分析表明，在癌症轨迹上，大多数运动行为结果没有显著变化。然而，探索性分析表明，男性和年轻的参与者在脑肿瘤诊断后降低运动水平的风险最大。在控制了相关的人口统计学和医学协变量后，这些分析保持不变。相对较高比例的脑肿瘤患者在整个癌症轨迹中以推荐水平进行锻炼。此外，这些患者具有独特的运动模式，可以通过选择人口统计学变量进行修改。这项初步研究为未来的研究提供了重要的信息数据，研究运动在诊断为神经系统恶性肿瘤的患者中的潜在作用。
BACKGROUND. Exercise may represent a supportive intervention that may complement existing neurooncologic therapies and address a multitude of therapy-induced debilitating side effects in patients with brain tumors. Given the limited evidence, the authors conducted a survey to examine the exercise patterns of brain tumor patients across the cancer trajectory.METHODS. Using a cross-sectional design, 386 brain turner patients who received treatment at the Brain Tumor Center at Duke University were sent a questionnaire that assessed self-reported exercise behavior prior to diagnosis, during adjuvant therapy, and after the completion of therapy.RESULTS. The response rate was 28% (106 of 383 patients). Descriptive analyses indicated that 42%, 38%, and 41% of participants, respectively, met national exercise prescription guidelines prior to diagnosis, during treatment, and after the completion of adjuvant therapy. Repeated measures analyses indicated no significant changes in the majority of exercise behavior outcomes over the cancer trajectory. However, exploratory analyses indicated that males and younger participants may be at the greatest risk of reducing exercise levels after a brain tumor diagnosis. These analyses remained unchanged after controlling for relevant demographic and medical covariates.CONCLUSIONS. A relatively high percentage of brain tumor patients are exercising at recommended levels across the cancer trajectory. Moreover, these patients have unique exercise patterns that may be modified by select demographic variables. This preliminary study provides important informative data for future studies examining the potential role of exercise in patients diagnosed with neurologic malignancies.