HYDROXYLAPATITE COATING OF POROUS IMPLANTS IMPROVES BONE INGROWTH AND INTERFACE ATTACHMENT STRENGTH
HYDROXYLAPATITE COATING OF POROUS IMPLANTS IMPROVES BONE INGROWTH AND INTERFACE ATTACHMENT STRENGTH
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DOI：
10.1002/jbm.820260803
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发表时间：
1992-08-01
期刊：
影响因子：
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通讯作者：
KAY, JF
中科院分区：
文献类型：
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作者：
COOK, SD;THOMAS, KA;KAY, JF
采用犬股骨经皮质种植体模型，研究了等离子喷涂羟基磷灰石（HA）涂层对骨长入程度和界面剪切附着强度的影响。通过烧结直径为500-710 μ m的球形Co-Cr-Mo颗粒来制造圆柱形植入物;标称植入物尺寸为5.95 +/- 0.05 mm直径× 18 mm长度。每个种植体的一半通过等离子喷涂技术涂有厚度为25-30 μ m的羟基磷灰石。使用严格的无菌技术，将植入物穿过双侧股骨皮质置入尺寸不足约0.05 mm的缺损处。在2、4、6、8、12、18、26和52周后，收获种植体并进行机械拔出试验和不脱钙组织学评价。HA涂层在多孔植入物上的应用在所有时间段都增强了骨长入量和界面附着强度。这些差异在4、6、12、18、26和52周时间段的骨长入百分比方面具有统计学显著性，并且在6、8、12、18和26周时间段的界面剪切强度值具有显著性差异。HA涂层种植体的界面强度和骨长入的发展速度也更快。没有观察到HA涂层的任何破坏、机械失效或生物吸收的证据。本研究的结果-证明了HA涂层在所有时间段的有益效果-被认为是由于使用配对比较，这使得可以评估可能被正常生物学变异性掩盖的细微差异。
The effect of a plasma-sprayed hydroxylapatite (HA) coating on the degree of bone ingrowth and interface shear attachment strength was investigated using a canine femoral transcortical implant model. Cylindrical implants were fabricated by sintering spherical Co-Cr-Mo particles 500-710-mu-m in diameter; the nominal implant dimensions were 5.95 +/- 0.05 mm diameter by 18 mm in length. One half of each implant was coated with hydroxylapatite, 25-30-mu-m in thickness, by a plasma-spray technique. Using strict aseptic technique, the implants were placed through both femoral cortices into defects approximately 0.05 mm undersized. After 2, 4, 6, 8, 12, 18, 26, and 52 weeks, the implants were harvested and subjected to mechanical pullout testing and undecalcified histologic evaluation. The application of the HA coating to porous implants enhanced both the amount of bone ingrowth and the interface attachment strength at all time periods. These differences were statistically significant for the percent of bone ingrowth at the 4-, 6-, 12-, 18-, 26-, and 52-week time periods, and interface shear strength values were significantly different at the 6-, 8-, 12-, 18-, and 26-week time periods. The rate of development of interface strength and bone ingrowth was also more rapid for the HA-coated implants. No evidence of any disruption, mechanical failure, or biologic resorption of the HA coating was observed. The results of the present study-demonstrating a beneficial effect of the HA coating at all time periods-are believed to be due to the use of paired comparisons, which allow assessment of subtle differences that might otherwise have been obscured by normal biological variability.