Protein Recognition by an Ensemble of Fluorescent DNA G-Quadruplexes
Protein Recognition by an Ensemble of Fluorescent DNA G-Quadruplexes
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DOI：
10.1002/anie.200804887
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Hamilton, Andrew D.
中科院分区：
文献类型：
--
作者：
Margulies, David;Hamilton, Andrew D.
嗅出蛋白质：荧光DNA G-四链体已被用于在单一溶液中为蛋白质构建多功能信号受体。将蛋白质样品引入系综导致用于明确识别的独特发射特征（参见方案，R=荧光团）。自组装的基于模式的蛋白质检测系统易于制造，具有高通量操作的潜力，并且具有处理小蛋白质样品的能力。
Sniffing out proteins: Fluorescent DNA G‐quadruplexes have been used for building versatile signaling receptors for proteins in a single solution. Introducing a protein sample to the ensemble results in a unique emission signature for unambiguous identification (see scheme, R=fluorophore). The self‐assembled, pattern‐based protein detection systems are easily fabricated, have the potential for high‐throughput operations, and have the ability to handle small protein samples.