Iron deficiency anemia and iron therapy effects on infant developmental test performance.
Iron deficiency anemia and iron therapy effects on infant developmental test performance.
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DOI：
10.1542/peds.79.6.981
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发表时间：
1987-06
期刊：
影响因子：
8
通讯作者：
B. Lozoff;G. Brittenham;A. Wolf;D. McClish;P. Kuhnert;E. Jimenez;R. Jiménez;Luis A. Mora;Ivonne Gomez;Dina Krauskoph
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文献类型：
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作者：
B. Lozoff;G. Brittenham;A. Wolf;D. McClish;P. Kuhnert;E. Jimenez;R. Jiménez;Luis A. Mora;Ivonne Gomez;Dina Krauskoph
在一项基于社区的双盲随机对照研究中，对191名12至23个月大的患有不同程度缺铁的哥斯达黎加婴儿进行了评估，以评估缺铁及其治疗的行为影响。在肌注或口服铁剂前、后1周和3个月进行贝利婴儿发育评定量表测试。适当的安慰剂治疗的对照组婴儿也进行了测试。即使考虑了出生、营养、家庭背景、父母智商和家庭环境等因素，患有缺铁性贫血的婴儿的智力和运动测试成绩也明显较低。一周后，无论是肌注铁剂还是口服铁剂，对分数的影响都不同于安慰剂治疗。3个月后，在贫血和缺铁都得到纠正的缺铁性贫血婴儿中，不再观察到较低的智力和运动测试分数(36%)。然而，在大多数患有更严重或慢性缺铁的初始贫血婴儿(%)中，智力和运动测试分数仍然显著较低。虽然不再贫血，但经过3个月的治疗后，他们仍然显示出铁缺乏的生化证据。这些持续较低的得分表明，要么是足够纠正贫血的铁剂疗法不足以扭转许多婴儿的行为和发育障碍，要么表明某些不良影响是长期的，这取决于婴儿缺铁性贫血的时间、严重程度或慢性病。
The behavioral effects of iron deficiency and its treatment were evaluated in a double-blind randomized controlled community-based study of 191 Costa Rican infants, 12 to 23 months of age, with various degrees of iron deficiency. The Bayley Scales of Infant Development were administered before and both 1 week and 3 months after IM or oral administration of iron. Appropriate placebo-treated control infants were also tested. Infants with iron deficiency anemia showed significantly lower mental and motor test scores, even after considering factors relating to birth, nutrition, family background, parental IQ, and the home environment. After 1 week, neither IM nor oral iron treatments differed from placebo treatment in effects on scores. After 3 months, lower mental and motor test scores were no longer observed among iron-deficient anemic infants whose anemia and iron deficiency were both corrected (36%). However, significantly lower mental and motor test scores persisted among the majority of initially anemic infants (64%) who had more severe or chronic iron deficiency. Although no longer anemic, they still showed biochemical evidence of iron deficiency after 3 months of treatment. These persistent lower scores suggest either that iron therapy adequate for correcting anemia is insufficient to reverse behavioral and developmental disturbances in many infants or that certain ill effects are long-lasting, depending on the timing, severity, or chronicity of iron deficiency anemia in infancy.