Novel Spinal Cord Stimulation Parameters in Patients with Predominant Back Pain
Novel Spinal Cord Stimulation Parameters in Patients with Predominant Back Pain
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DOI：
10.1111/ner.12032
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发表时间：
2013-07-01
期刊：
影响因子：
2.8
通讯作者：
Morgan, Donna
中科院分区：
文献类型：
--
作者：
Tiede, Jeffrey;Brown, Lora;Morgan, Donna
目的在一项为期4天的经皮试验中，检查新型高频脊髓刺激治疗慢性显性背痛患者队列的可行性。设计前瞻性、多中心、开放标签的先导试验。背景和患者：24名背痛大于腿痛的患者在美国5个中心接受了脊髓刺激的试验。患者使用市售脊髓刺激器完成经皮试验。然后将植入的电极导线连接到新型外部刺激装置，并对患者进行额外的四天试验。结果测量疼痛强度等级、主观描述和患者偏好。结果与基线相比，研究刺激的总体疼痛评分（8.68至2.03，[p < 0.001]）和背痛评分（8.12至1.88，[p < 0.001]）有显著改善。24例患者中有21例（88%）首选试验用刺激而非市售系统。结论：当接受高频脊髓电刺激治疗时，主要背痛患者的总体疼痛和背痛明显减轻。
Objectives To examine the feasibility of novel high-frequency spinal cord stimulation therapy in a cohort of patients with chronic predominant back pain during a four day, percutaneous trial. Design Prospective, multicenter open label pilot trial. Setting and Patients:Twenty-four patients with back pain greater than leg pain who were candidates for spinal cord stimulation were trialed at five U.S. centers. Interventions Patients completed a percutaneous trial with a commercially available spinal cord stimulator. The implanted leads were then connected to the novel external stimulation device and patients were trialed for an additional four days. Outcome Measures Pain intensity ratings, subjective descriptions, and patients' preference. Results There was significant improvement from baseline in overall pain scores (8.68 to 2.03, [p < 0.001]) and back pain scores (8.12 to 1.88, [p < 0.001]) with the investigational stimulation. The investigational stimulation was preferred to the commercially available systems in 21 of 24 patients (88%). Conclusions Patients with predominant back pain reported a substantial reduction in overall pain and back pain when trialed with high-frequency spinal cord stimulation therapy.