Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
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DOI：
10.1016/j.cell.2009.07.049
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发表时间：
2009-10-16
期刊：
影响因子：
64.5
通讯作者：
Ernfors, Patrik
中科院分区：
文献类型：
--
作者：
Adameyko, Igor;Lallemend, Francois;Ernfors, Patrik
目前的观点认为，色素细胞，即黑素细胞，来源于神经管背侧产生的神经嵴细胞，并在表皮下迁移，分布在皮肤的所有部位。在这里，我们确定生长的神经投射到整个身体作为一个包含雪旺细胞前体（SCPs）的干细胞/祖位，大量皮肤黑素细胞起源于此。scp是由于神经嵴腹侧迁移通路中Hmx1同源盒基因功能缺乏神经元规范而产生的。雪旺细胞和黑素细胞的发育共享与神经接触密切相关的神经胶质细胞和黑素细胞命运的信号分子，并以相反的方式受到神经调节蛋白和可溶性信号（包括胰岛素样生长因子和血小板衍生生长因子）的调节。这些结果揭示了scp是黑素细胞的细胞起源，并对发育过程中调节皮肤色素沉着、健康和色素沉着障碍的分子机制具有广泛的意义。
Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin. Here, we identify growing nerves projecting throughout the body as a stem/progenitor niche containing Schwann cell precursors (SCPs) from which large numbers of skin melanocytes originate. SCPs arise as a result of lack of neuronal specification by Hmx1 homeobox gene function in the neural crest ventral migratory pathway. Schwann cell and melanocyte development share signaling molecules with both the glial and melanocyte cell fates intimately linked to nerve contact and regulated in an opposing manner by Neuregulin and soluble signals including insulin-like growth factor and platelet-derived growth factor. These results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders.