Efficacy and Safety of Radiofrequency Ablation for Benign Thyroid Nodules: A Prospective Multicenter Study.
Efficacy and Safety of Radiofrequency Ablation for Benign Thyroid Nodules: A Prospective Multicenter Study.
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DOI：
10.3348/kjr.2018.19.1.167
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发表时间：
2018-01
影响因子：
4.8
通讯作者：
Na DG
中科院分区：
文献类型：
--
作者：
Jung SL;Baek JH;Lee JH;Shong YK;Sung JY;Kim KS;Lee D;Kim JH;Baek SM;Sim JS;Na DG
在一项多中心研究中，评估由经过培训的放射科医生按照统一方案进行甲状腺射频（RF）消融治疗良性甲状腺结节的有效性和安全性。从2010年至2011年，从5家机构入组了345例符合合格标准的患者（男：女= 43：302;平均年龄± SD = 46.0 ± 12.7岁，范围= 15-79）的345个结节。消融前，平均体积为14.2 ± 13.2 mL（1.1-80.8 mL）。治疗后12个月或更长时间，随访了276个病灶，包括248个实性结节和28个主要为囊性结节。所有术者均使用冷头端射频系统和两种标准技术（经胸入路和移动发射技术）进行射频消融。对射频消融后12个月的减容（主要结局）、治疗成功率、症状改善以及美容问题和并发症进行了评价。应用多元线性回归分析确定独立预测减容的因素。12个月时的平均减容率为80.3%（n = 276），24、36、48和60个月随访时分别为84.3%（n = 198）、89.2%（n = 128）、91.9%（n = 57）和95.3%（n = 6）。治疗成功率为97.8%。平均症状和美容评分均显示显著改善（p < 0.001）。严重并发症发生率为1.0%（3/276）。固体和施加的能量是预测体积减少的独立因素。由来自多个机构的经过培训的放射科医生使用统一的方案和类似器械进行的放射消融术治疗良性甲状腺结节是有效和安全的。
To assess the efficacy and safety of thyroid radiofrequency (RF) ablation for benign thyroid nodules by trained radiologists according to a unified protocol in a multi-center study. From 2010 to 2011, 345 nodules from 345 patients (M:F = 43:302; mean age ± SD = 46.0 ± 12.7 years, range = 15–79) who met eligibility criteria were enrolled from five institutions. At pre-ablation, the mean volume was 14.2 ± 13.2 mL (1.1–80.8 mL). For 12 months or longer after treatment, 276 lesions, consisting of 248 solid and 28 predominantly cystic nodules, were followed. All operators performed RF ablation with a cool-tip RF system and two standard techniques (a transisthmic approach and the moving-shot technique). Volume reduction at 12 months after RF ablation (the primary outcome), therapeutic success, improvement of symptoms as well as of cosmetic problems, and complications were evaluated. Multiple linear regression analysis was applied to identify factors that were independently predictive of volume reduction. The mean volume reduction at 12 months was 80.3% (n = 276) and at the 24-, 36-, 48-, and 60-month follow-ups 84.3% (n = 198), 89.2% (n = 128), 91.9% (n = 57), and 95.3% (n = 6), respectively. Our therapeutic success was 97.8%. Both mean symptom and cosmetic scores showed significant improvements (p < 0.001). The rate of major complications was 1.0% (3/276). Solidity and applied energy were independent factors that predicted volume reduction. Radiofrequency ablation performed by trained radiologists from multiple institutions using a unified protocol and similar devices was effective and safe for treating benign thyroid nodules.
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影响因子：
4.8
作者：
Na DG;Lee JH;Jung SL;Kim JH;Sung JY;Shin JH;Kim EK;Lee JH;Kim DW;Park JS;Kim KS;Baek SM;Lee Y;Chong S;Sim JS;Huh JY;Bae JI;Kim KT;Han SY;Bae MY;Kim YS;Baek JH;Korean Society of Thyroid Radiology (KSThR);Korean Society of Radiology
通讯作者：
Korean Society of Radiology
影响因子：
2.6
作者：
Baek, Jung Hwan;Moon, Won-Jin;Lee, Ducky
通讯作者：
Lee, Ducky
影响因子：
2.9
作者：
Deandrea, Maurilio;Limone, Paolo;Garberoglio, Roberto
通讯作者：
Garberoglio, Roberto
影响因子：
4.8
作者：
Baek JH;Ha EJ;Choi YJ;Sung JY;Kim JK;Shong YK
通讯作者：
Shong YK
影响因子：
4.8
作者：
Ha EJ;Baek JH;Lee JH
通讯作者：
Lee JH