Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury.
Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury.
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葡萄籽原花青素可改善辐射引起的肺损伤。
DOI：
10.1111/jcmm.12276
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发表时间：
2014-07
影响因子：
5.3
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Huang Y;Liu W;Liu H;Yang Y;Cui J;Zhang P;Zhao H;He F;Cheng Y;Ni J;Cai J;Li B;Gao F
放射性肺损伤（RILI）是胸部放射治疗的一种潜在的致命性和剂量限制性并发症。研究葡萄籽原花青素（GSPs）对RILI的保护作用。我们的研究表明，GSPs治疗后，急性和晚期RILI得到改善，这可能是通过抑制TGF-β1/Smad 3/Snail信号通路和调节Th 1/Th 2细胞源性细胞因子（IFN-γ、IL-4和IL-13）的水平。此外，通过限制成纤维细胞功能的GSPs处理也维持了持续的高水平PGE 2。电子自旋共振（ESR）分析表明，GSPs可剂量依赖性地清除·OH，这可能是GSPs减轻脂质过氧化和肺细胞凋亡的机制之一。在体外，GSPs放射增敏肺癌细胞A549，同时减轻正常肺泡上皮细胞RLE-6 TN的辐射损伤。结果表明，GSPs通过清除自由基和调节RILI相关细胞因子对RILI小鼠具有保护作用，提示GSPs可能是RILI的一种新的保护剂。
Radiation-induced lung injury (RILI) is a potentially fatal and dose-limiting complication of thoracic radiotherapy. This study was to investigate the protective effects of grape seed pro-anthocyanidins (GSPs), an efficient antioxidant and anti-carcinogenic agent, on RILI. In our study, it was demonstrated that acute and late RILI was ameliorated after GSPs treatment possibly through suppressing TGF-β1/Smad3/Snail signalling pathway and modulating the levels of cytokines (interferon-γ, IL-4 and IL-13) derived from Th1/Th2 cells. In addition, a sustained high level of PGE2 was also maintained by GSPs treatment to limited fibroblast functions. As shown by electron spin resonance spectrometry, GSPs could scavenge hydroxyl radical (•OH) in a dose-dependent manner, which might account for the mitigation of lipid peroxidation and consequent apoptosis of lung cells. In vitro, GSPs radiosensitized lung cancer cell A549 while mitigating radiation injury on normal alveolar epithelial cell RLE-6TN. In conclusion, the results showed that GSPs protects mice from RILI through scavenging free radicals and modulating RILI-associated cytokines, suggesting GSPs as a novel protective agent in RILI.
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影响因子：
4.7
作者：
Mantena, Sudheer K.;Baliga, Manjeshwar S.;Katiyar, Santosh K.
通讯作者：
Katiyar, Santosh K.
DOI：
10.1084/jem.194.6.809
发表时间：
2001-09-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lee CG;Homer RJ;Zhu Z;Lanone S;Wang X;Koteliansky V;Shipley JM;Gotwals P;Noble P;Chen Q;Senior RM;Elias JA
通讯作者：
Elias JA
影响因子：
4
作者：
Castanares, Cristina;Redondo-Horcajo, Mariano;Rodriguez-Pascual, Fernando
通讯作者：
Rodriguez-Pascual, Fernando
影响因子：
5.7
作者：
Khan, MA;Van Dyk, J;Hill, RP
通讯作者：
Hill, RP
DOI：
10.1016/j.ijrobp.2006.12.056
发表时间：
2007-05-01
影响因子：
7
作者：
Fleckenstein, Katharina;Zgonjanin, Larisa;Vujaskovic, Zeljko
通讯作者：
Vujaskovic, Zeljko