Development of a Sputtered Nanocarbon Film Based Microdisk Array Electrode for the Highly Stable Detection of Serotonin
Development of a Sputtered Nanocarbon Film Based Microdisk Array Electrode for the Highly Stable Detection of Serotonin
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DOI：
10.1002/elan.201000636
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发表时间：
2011-04
期刊：
影响因子：
3
通讯作者：
Hiroaki Inokuchi;Dai Kato;A. Ueda;O. Niwa
中科院分区：
文献类型：
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作者：
Hiroaki Inokuchi;Dai Kato;A. Ueda;O. Niwa
我们报道了一种基于纳米碳膜的微盘阵列电极，具有非常稳定的电化学响应，用于测量血清素。采用电子回旋共振溅射法在硅衬底上制备了纳米碳薄膜，并采用光刻法制备了基于纳米碳薄膜的微盘阵列电极。阵列电极由335个直径为10 µm的微圆盘组成。每个微盘的中心到中心的距离为100 µm。比较了基于纳米碳膜的微盘阵列电极和基于金膜的微盘阵列电极的电化学性能。在微加工之前，纳米碳和金膜电极（直径均为2 mm）对1 µM血清素的连续伏安测量均显示出稳定的响应。此外，每个微盘阵列电极表现出S形响应。由于微电极效应，获得的电流密度高于常规尺寸的电极。然而，基于金膜的微盘阵列电极在0.45 V（相对于Ag/AgCl）下的电流值迅速下降，并在十次电位扫描后降至其初始值的30%。相比之下，基于纳米碳膜的微盘阵列电极在相同的测量条件下仅降低2%。尽管在微电极处有超过10倍的电流密度，但我们的纳米碳膜在抑制血清素吸附方面表现出优异的性能。
We report a nanocarbon film based microdisk array electrode with an extremely stable electrochemical response for measuring serotonin. The nanocarbon film was formed on a silicon substrate with an electron cyclotron resonance sputtering method, and the nanocarbon film based microdisk array electrode was fabricated using photolithography. The array electrode consists of 335 microdisks with a diameter of 10 µm. The center-to-center distance of each microdisk is 100 µm. The electrochemical properties of the nanocarbon film based microdisk array electrode are compared with those of a gold film based array electrode. Before microfabrication, both nanocarbon and gold film electrodes (both 2 mm in diameter) showed steady responses for the continuous voltammetric measurement of 1 µM of serotonin. Moreover, each microdisk array electrode exhibited a sigmoidal response. The obtained current densities were higher than those of conventional sized electrodes owing to the microelectrode effect. However, the current value at 0.45 V vs. Ag/AgCl at the gold film based microdisk array electrode decreased rapidly and fell to 30 % of its initial value after ten potential scans. In contrast, the nanocarbon film based microdisk array electrode decreased only 2 % under the same measurement condition. Despite the fact that there was more than 10 times the current density at the microelectrode, our nanocarbon film showed excellent performance in suppressing serotonin adsorption.