Effect of nanocellulose length on emulsion stabilization and microparticle synthesis
Effect of nanocellulose length on emulsion stabilization and microparticle synthesis
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DOI：
10.1038/s41428-022-00748-3
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发表时间：
2023-01
期刊：
影响因子：
2.8
通讯作者：
Shuji Fujisawa;Reina Tanaka;Y. Hayashi;Y. Yabuhara;M. Kume;Tsuguyuki Saito
中科院分区：
文献类型：
--
作者：
Shuji Fujisawa;Reina Tanaka;Y. Hayashi;Y. Yabuhara;M. Kume;Tsuguyuki Saito
表面工程对于设计具有化学和物理性质的纳米/微粒至关重要，这些纳米/微粒可用于各种应用，如制药、化妆品和治疗。纳米纤维素由于其生物相容性和生理条件下的化学稳定性而满足了对颗粒表面的需求。采用模板法制备了纳米纤维素包被聚合物微粒子。虽然乳液稳定对于控制微颗粒的大小和形状至关重要，但最佳乳液制备条件尚未确定。通过改变纳米纤维素的长度，研究了适合微颗粒合成的乳液稳定条件。采用三种不同长度的纳米纤维素来控制水相的粘度。研究发现，稳定乳液的最佳纳米纤维素浓度随纳米纤维素长度的变化而变化，较长的纳米纤维素由于其较高的粘度，在较低浓度下能有效地稳定乳液。成功地从稳定的乳剂中制备了纳米纤维素包被微粒。由较短的纳米纤维素稳定的乳剂被发现更适合于制备细颗粒，因为纳米纤维素有效地覆盖了乳剂中油滴的表面，阻止了聚并。这些结果将有助于了解乳液稳定机制和乳液模板纳米纤维素基材料的发展。
Surface engineering is crucial for designing nano/microparticles with chemical and physical properties for various applications, such as pharmaceuticals, cosmetics, and therapeutics. Nanocelluloses satisfy the demand for particle surfaces owing to their biocompatibilities and chemical stabilities under physiological conditions. Nanocellulose-coated polymer microparticles are prepared by templating the structure of nanocellulose-stabilized monomer-in-water emulsions. Although emulsion stabilization is essential for controlling the sizes and shapes of microparticles, optimum emulsion preparation conditions have not been determined. This study investigated the emulsion stabilization conditions suitable for microparticle syntheses by changing the lengths of nanocelluloses. Three nanocelluloses of different lengths were used to control the viscosities of aqueous continuous phases. The optimal nanocellulose concentration for stabilizing the emulsion was found to vary with nanocellulose length, with longer nanocelluloses efficiently stabilizing the emulsion at lower concentrations due to the higher viscosity. Nanocellulose-coated microparticles were successfully prepared from the stable emulsions. Emulsions stabilized by shorter nanocelluloses were found to be more suitable for the preparation of fine microparticles because the nanocelluloses effectively covered the surfaces of oil droplets in the emulsions, precluding coalescence. These results will aid in the understanding of emulsion stabilization mechanisms and the development of emulsion-templated nanocellulose-based materials.