Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method.
Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method.
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DOI：
10.1021/acscentsci.6b00091
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发表时间：
2016-05-25
影响因子：
18.2
通讯作者：
Baran PS
中科院分区：
文献类型：
--
作者：
Horn EJ;Rosen BR;Baran PS
尽管有机分子的制备电解在过去的一个世纪里一直是一个活跃的研究领域，但现代合成化学家通常不愿采用这项技术。事实上，与传统的试剂转化相比，电化学方法具有许多优点，如较高的官能团耐受性、温和的条件以及固有的可扩展性和可持续性。在这篇展望中，我们重点介绍了复杂分子合成背景下的电化学反应的说明性例子，展示了电化学反应相对于传统的基于试剂的方法的内在好处。我们希望这一领域很快就能在合成界得到广泛采用。讨论了在复杂有机分子的合成和功能化中使用固有的可伸缩但未得到充分利用的电化学方法。下面展示了精选的示例，以突出此支持工具的优势。
While preparative electrolysis of organic molecules has been an active area of research over the past century, modern synthetic chemists have generally been reluctant to adopt this technology. In fact, electrochemical methods possess many benefits over traditional reagent-based transformations, such as high functional group tolerance, mild conditions, and innate scalability and sustainability. In this Outlook we highlight illustrative examples of electrochemical reactions in the context of the synthesis of complex molecules, showcasing the intrinsic benefits of electrochemical reactions versus traditional reagent-based approaches. Our hope is that this field will soon see widespread adoption in the synthetic community. The use of innately scalable yet underutilized electrochemical methods for the synthesis and functionalization of complex organic molecules is discussed. Selected examples are shown to highlight the benefits of this enabling tool.