Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients
Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients
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DOI：
10.1111/bcp.12636
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发表时间：
2015-09-01
影响因子：
3.4
通讯作者：
Kees, Martin G.
中科院分区：
文献类型：
--
作者：
Schleibinger, Michael;Steinbach, Catherine L.;Kees, Martin G.
目的评价全头孢曲松和非结合头孢曲松在重症监护病房（ICU）患者体内的药代动力学及其蛋白结合特性。方法20例患者（m/f 15/5），年龄25 ~ 86岁，体重60 ~ 121kg， APACHE指数7 ~ 40，估计肾小球滤过率19 ~ 157ml min(-1)，白蛋白11.7 ~ 30.1g l(-1)，总胆红素
AimsThe aim of the present study was to assess the pharmacokinetics of total and unbound ceftriaxone in intensive care unit (ICU) patients and its protein binding characteristics.MethodsTwenty patients (m/f 15/5, age 25-86 years, body weight 60-121kg, APACHE II 7-40, estimated glomerular filtration rate 19-157ml min(-1), albumin 11.7-30.1g l(-1), total bilirubin