Augurin stimulates the hypothalamo‐pituitary‐adrenal axis via the release of corticotrophin‐releasing factor in rats
Augurin stimulates the hypothalamo‐pituitary‐adrenal axis via the release of corticotrophin‐releasing factor in rats
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DOI：
10.1111/j.1476-5381.2010.00655.x
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发表时间：
2010-04
影响因子：
7.3
通讯作者：
J. Tadross;M. Patterson;K. Suzuki;K. Beale;C. Boughton;Kl Smith;S. Moore;M. Ghatei;S. Bloom
中科院分区：
文献类型：
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作者：
J. Tadross;M. Patterson;K. Suzuki;K. Beale;C. Boughton;Kl Smith;S. Moore;M. Ghatei;S. Bloom
背景和目的：分泌肽的功能表征可为新型治疗药物的开发提供依据。Augurin是最近发现的一种功能未知的分泌肽，在多种内分泌组织中表达，并在包括下丘脑在内的大脑区域表达。因此，我们研究了下丘脑注射奥古林对雄性Wistar大鼠下丘脑-垂体-肾上腺(HPA)轴的影响。
Background and purpose: The functional characterization of secreted peptides can provide the basis for the development of novel therapeutic agents. Augurin is a recently identified secreted peptide of unknown function expressed in multiple endocrine tissues, and in regions of the brain including the hypothalamus. We therefore investigated the effect of hypothalamic injection of augurin on the hypothalamo‐pituitary‐adrenal (HPA) axis in male Wistar rats.