Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study.
Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study.
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多形核白细胞与固定关节炎关节的髌骨软骨的相互作用：扫描电子显微镜研究。
DOI：
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发表时间：
1989
影响因子：
27.4
通讯作者：
W. B. van den Berg
中科院分区：
文献类型：
--
作者：
P. van Lent;F. Wilms;W. B. van den Berg
抗原诱导的小鼠关节炎膝关节的短期固定（7天）导致多形核白细胞附着于软骨表面和严重的软骨损伤。在髌骨软骨表面的事件进行了研究，通过扫描电子显微镜，并与非固定的关节炎关节中发现的变化进行比较。在第7天，固定的关节炎关节显示出关节软骨，其被一层坏死物质和细胞残余物覆盖。此外，炎症细胞，清楚地附着在软骨上，显示出它们的膜的大突起。此外，软骨表面显示出许多不同大小和深度的裂缝。这些软骨变化在固定的关节炎关节比在非固定的关节炎关节中更明显，并且仅在前者中发现透明细胞粘附。这些发现表明，发炎小鼠膝关节的固定导致损伤增加，因此尽管临床固定用于缓解疼痛，但这也可能有损伤关节软骨的风险。
Short term immobilisation (seven days) of an antigen induced arthritic knee joint of the mouse led to attachment of polymorphonuclear leucocytes to the cartilage surface and severe cartilage damage. The events at the patellar cartilage surface were studied by scanning electron microscopy and compared with the changes found in non-immobilised arthritic joints. At day 7 the immobilised arthritic joint showed an articular cartilage which was covered by a mat of fibrinous material and cell remnants. Moreover, inflammatory cells, clearly attached to the cartilage, showed large protrusions of their membranes. The cartilage surface, furthermore, showed numerous fissures of varying size and depth. These cartilage changes were much more pronounced in immobilised arthritic joints than in non-immobilised arthritic joints, and clear cell adhesion was exclusively found in the former. These findings show that immobilisation of inflamed mouse knee joints leads to increased damage and thus although clinical immobilisation is used to relieve pain, this may also risk damage to the articular cartilage.
血液透析粒细胞减少症中促粘附表面糖蛋白的表达增加。
DOI：
10.1056/nejm198502213120801
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Arnaout,MA;Hakim,RM;Todd3rd,RF;Dana,N;Colten,HR
通讯作者：
Colten,HR