Rapid Eye Movement Sleep, Sleep Continuity and Slow Wave Sleep as Predictors of Cognition, Mood, and Subjective Sleep Quality in Healthy Men and Women, Aged 20-84 Years
Rapid Eye Movement Sleep, Sleep Continuity and Slow Wave Sleep as Predictors of Cognition, Mood, and Subjective Sleep Quality in Healthy Men and Women, Aged 20-84 Years
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DOI：
10.3389/fpsyt.2018.00255
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发表时间：
2018-06-22
影响因子：
4.7
通讯作者：
Dijk, Derk-Jan
中科院分区：
文献类型：
--
作者：
della Monica, Ciro;Johnsen, Sigurd;Dijk, Derk-Jan
睡眠及其子状态被认为对整个生命周期的大脑功能很重要，但睡眠的哪些方面与认知，情绪和自我报告的睡眠质量的各个方面有关尚未详细确定。采用多导睡眠图、定量脑电图（EEG）分析和自我报告对206名年龄在20-84岁之间、无睡眠主诉的健康男性和女性的睡眠进行定量。通过一天中安排的五项评估来量化唤醒脑功能，这些评估涵盖了跨认知领域的客观评估表现，包括持续注意力和唤醒、决策和反应时间、运动和序列控制、工作记忆和执行功能以及警觉性、情绪和影响的自我报告。控制年龄和性别，自我报告的睡眠质量与觉醒次数呈负相关，与快速眼动（REM）睡眠持续时间呈正相关，但与慢波睡眠（SWS）测量无显著相关性。仅对年龄进行控制的结果显示，女性的客观和主观睡眠质量之间的联系要比男性强得多。对51项绩效指标的分析表明，在控制了年龄和性别后，更少的觉醒和更多的REM睡眠与更好的执行功能测试目标神经元任务的绩效显著相关。因子分析的个人表现措施确定了四个潜在变量标记情绪/唤醒，反应时间，准确性和视觉感知灵敏度。情绪/唤醒随年龄增长而改善，反应时间变慢，而准确性和视知觉敏感度随年龄变化不大。在控制了性别和年龄之后，观察到睡眠和因子分数之间名义上的显著关联，使得SWS越多，响应时间越快，并且当个体醒来更频繁或REM睡眠较少时，准确性降低。这些数据确定了SWS对处理速度的积极贡献，特别是突出了睡眠连续性和REM睡眠对成人寿命期间主观睡眠质量和性能准确性的重要性。这些发现证明了进一步研究睡眠连续性和REM睡眠对大脑功能的贡献。
Sleep and its sub-states are assumed to be important for brain function across the lifespan but which aspects of sleep associate with various aspects of cognition, mood and self-reported sleep quality has not yet been established in detail. Sleep was quantified by polysomnography, quantitative Electroencephalogram (EEG) analysis and self-report in 206 healthy men and women, aged 20-84 years, without sleep complaints. Waking brain function was quantified by five assessments scheduled across the day covering objectively assessed performance across cognitive domains including sustained attention and arousal, decision and response time, motor and sequence control, working memory, and executive function as well as self-reports of alertness, mood and affect. Controlled for age and sex, self-reported sleep quality was negatively associated with number of awakenings and positively associated with the duration of Rapid Eye Movement (REM) sleep, but no significant associations with Slow Wave Sleep (SWS) measures were observed. Controlling only for age showed that associations between objective and subjective sleep quality were much stronger in women than in men. Analysis of 51 performance measures demonstrated that, after controlling for age and sex, fewer awakenings and more REM sleep were associated significantly with better performance on the Goal Neglect task, which is a test of executive function. Factor analysis of the individual performance measures identified four latent variables labeled Mood/Arousal, Response Time, Accuracy, and Visual Perceptual Sensitivity. Whereas Mood/Arousal improved with age, Response Times became slower, while Accuracy and Visual perceptual sensitivity showed little change with age. After controlling for sex and age, nominally significant association between sleep and factor scores were observed such that Response Times were faster with more SWS, and Accuracy was reduced where individuals woke more often or had less REM sleep. These data identify a positive contribution of SWS to processing speed and in particular highlight the importance of sleep continuity and REM sleep for subjective sleep quality and performance accuracy across the adult lifespan. These findings warrant further investigation of the contribution of sleep continuity and REM sleep to brain function.