Genomic Exploration of the Hemiascomycetous Yeasts:: 21.: Comparative functional classification of genes
Genomic Exploration of the Hemiascomycetous Yeasts:: 21.: Comparative functional classification of genes
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DOI：
10.1016/s0014-5793(00)02292-4
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发表时间：
2000-12-22
期刊：
影响因子：
3.5
通讯作者：
Weissenbach, J
中科院分区：
文献类型：
--
作者：
Gaillardin, C;Duchateau-Nguyen, G;Weissenbach, J
我们通过BLASTX搜索，利用13种22000个新发现的基因，探索了半子囊酵母菌的生物多样性。在酿酒酵母中没有明确同源性的基因在几个物种中似乎是保守的，这表明它们最近被酿酒酵母丢失了。他们经常识别出众所周知的物种特有特征。通过水平转移获得基因的情况似乎很少发生，如果有的话。所有已鉴定的基因都被归因于功能类。不同物种的功能类有不同的表现。通过功能聚类进行的物种分类与rDNA系统发育大致平行，快速进化的子囊菌特有基因在物种和功能之间的不均匀分布被证明对这种聚类有很大贡献。少数几个基因家族扩增的案例被记录下来，但没有观察到酵母物种的功能分化与基因家族大小变化之间的普遍相关性。因此，酵母生物多样性似乎是有限的特定物种基因丢失或复制的结果，在很大程度上是由于专用于特定功能的基因和调节因子的快速进化。(C)2000年欧洲生化学会联合会。爱思唯尔科学公司出版。版权所有。
We explored the biological diversity of hemiascomycetous yeasts using a set of 22 000 newly identified genes in 13 species through BLASTX searches. Genes without clear homologue in Saccharomyces cervisiae appeared to be conserved in several species, suggesting that they were recently lost by S. cervisiae. They often identified well-known species-specific traits. Cases of gene acquisition through horizontal transfer appeared to occur very rarely if at all. All identified genes were ascribed to functional classes. Functional classes were differently represented among species. Species classification by functional clustering roughly paralleled rDNA phylogeny, Unequal distribution of rapidly evolving, ascomycete-specific, genes among species and functions was shown to contribute strongly to this clustering. A few cases of gene family amplification were documented, but no general correlation could be observed between functional differentiation of yeast species and variations of gene family sizes. Yeast biological diversity seems thus to result from limited species-specific gene losses or duplications, and for a large part from rapid evolution of genes and regulatory factors dedicated to specific functions. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.