An in vitro study of the projections of enteric vasoactive intestinal polypeptide-immunoreactive neurons in the human colon.
An in vitro study of the projections of enteric vasoactive intestinal polypeptide-immunoreactive neurons in the human colon.
复制标题
人类结肠中肠血管活性肠多肽免疫反应性神经元投射的体外研究。
DOI：
10.1016/0016-5085(90)90003-j
复制
发表时间：
1990
期刊：
影响因子：
29.4
通讯作者：
J. Polak
中科院分区：
文献类型：
--
作者：
T. Domoto;A. Bishop;M. Oki;J. Polak
人类结肠肽能神经控制的解剖学基础在很大程度上是未知的。在这项研究中，在体外逆行追踪方法已被用于新鲜的人结肠，以确定肠神经的投射途径，特别是那些含有血管活性肠肽，最丰富和有效的肠道神经肽之一。粘膜下神经丛的两个组成部分被确定，内一个突出到固有层，和外的环形肌。粘膜下神经丛内各方向的突起长度可达5-14 mm。肌间神经节细胞投射到纵向和环形肌肉，最多只有5 mm的距离。含有血管活性肠多肽的神经亚群主要来自粘膜下神经丛，并投射到6.5 mm肛门，5 mm口腔，和14 mm内的粘膜下层粘膜或环形肌肉。这些发现为人类结肠的神经解剖学提供了全新的数据，并可能有助于理解结肠分泌和运动的神经控制。
The anatomical basis of the peptidergic neural control of the human colon is largely unknown. In this study, in vitro retrograde tracing methods have been used on fresh human colon to determine the projection pathways of the enteric nerves and, in particular, those containing vasoactive intestinal polypeptide, one of the most abundant and potent of the gut neuropeptides. Two components of the submucous plexus were identified, the inner one projecting to the lamina propria, and the outer to the circular muscle. The lengths of projections within the submucous plexus were up to 5–14 mm in all directions. Myenteric ganglion cells projected to both longitudinal and circular muscles, for distances of up to only 5 mm. The subpopulation of nerves containing vasoactive intestinal polypeptide arose mainly from the submucous plexus and projected up to 6.5 mm anally, 5 mm orally, and 14 mm within the submucous layer to the mucosa or circular muscle. These findings provide entirely new data on the neuroanatomy of the human colon and may help in the understanding of the neural control of colonic secretion and motility.
粘膜下神经丛的运动神经元调节犬近端结肠环形肌的电活动。
DOI：
10.1113/jphysiol.1986.sp016286
发表时间：
1986
期刊：
The Journal of physiology
影响因子：
--
作者：
Sanders,KM;Smith,TK
通讯作者：
Smith,TK