Rapamycin reduces seizure frequency in tuberous sclerosis complex.
Rapamycin reduces seizure frequency in tuberous sclerosis complex.
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DOI：
10.1177/0883073808324535
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发表时间：
2009-04
影响因子：
1.9
通讯作者：
Koenig MK
中科院分区：
文献类型：
--
作者：
Muncy J;Butler IJ;Koenig MK
作者报告了一名患有结节性硬化症的10岁女孩，她已经接受雷帕霉素治疗10个月以控制癫痫发作。起始剂量为0.05 mg/kg/d，逐渐滴定至有效剂量0.15 mg/kg/d。雷帕霉素治疗可显著降低癫痫发作频率。需要进一步的研究来客观地研究雷帕霉素对结节性硬化症的益处，并阐明其控制癫痫发作的机制。
The authors present a 10-year-old girl with tuberous sclerosis complex who has been receiving rapamycin for 10 months for seizure control. She was started at 0.05 mg/kg/d and titrated to an effective dose of 0.15 mg/kg/d. There was a dramatic reduction in seizure frequency with rapamycin therapy. Further studies are needed to objectively investigate the benefits of rapamycin in tuberous sclerosis complex and to clarify its mechanism of seizure control.
影响因子：
11.2
作者：
Zeng, Ling-Hui;Xu, Lin;Wong, Michael
通讯作者：
Wong, Michael