D-dimer level is associated with the extent of pulmonary embolism
D-dimer level is associated with the extent of pulmonary embolism
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DOI：
10.1016/j.thromres.2006.08.006
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发表时间：
2007-01-01
影响因子：
7.5
通讯作者：
Sandset, P. M.
中科院分区：
文献类型：
--
作者：
Ghanima, W.;Abdelnoor, M.;Sandset, P. M.
目的：我们的目的是研究D-二聚体的水平和肺栓塞（PE）的严重程度之间的相关性，确定由各种生化和放射学预后标志物，以探讨潜在的价值D-二聚体作为PE的严重程度的预后标志物。患者和方法：PE诊断在100个连续的门诊患者多探测器计算机断层扫描。1例患者被排除，最终队列由99例患者组成。评估肺动脉阻塞指数（PAOI）和右心室/左心室（RV/LV）比值。结果：D-二聚体的中位数为5.0 mg/L（四分位距：1.8，12.2）。log D-二聚体、log RV/12 V（r=0.45）、tog PAOI（r=0.5）和PaO 2（r=0.40）之间存在显著相关性。多变量分析显示，调整年龄、性别和症状持续时间后，tog D-二聚体与tog RV/LV比值（r=0.54）和tog PAOI（r=0.52）之间的相关性增加。D-二聚体水平与PE的最近端水平之间存在显著相关性（p
Objectives: Our aim was to study the association between the level of D-dimer and the severity of pulmonary embolism (PE) as determined by various biochemical and radiological prognostic markers in order to investigate the potential value of D-dimer as a prognostic marker for the severity of PE.Patients and methods: PE was diagnosed in 100 consecutive out-patients by multi-detector computerized tomography. One patient was excluded and the final cohort consisted of 99 patients. Pulmonary Artery Obstruction Index (PAOI) and Right Ventricular/Left Ventricular (RV/LV) ratio were assessed. Results: The median value for D-dimer was 5.0 mg/L (inter-quartile range: 1.8, 12.2). There was a significant association between log D-dimer, and between log RV/ 12V (r=0.45), tog PAOI (r=0.5), and PaO2 (r=0.40). The multivariate analysis showed an increased association between tog D-dimer and between tog RV/LV ratio (r=0.54) and tog PAOI (r=0.52) after adjusting for age, gender and for the duration of symptoms. Significant association was found between the level of D-dimer and the most proximal level of PE (p