Association of noise exposure, plasma microRNAs with arterial stiffness among Chinese workers.
Association of noise exposure, plasma microRNAs with arterial stiffness among Chinese workers.
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中国工人噪声暴露、血浆 microRNA 与动脉僵硬度的关系
DOI：
10.1016/j.envpol.2022.120002
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发表时间：
2022-10-15
期刊：
影响因子：
--
通讯作者：
Chen, Weihong
中科院分区：
文献类型：
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作者：
Wang, Dongming;Xiao, Yang;Chen, Weihong
据报道，长期噪声暴露会损害心血管系统，但职业性噪声暴露与动脉僵硬(AS)之间的关系及其潜在机制仍不清楚。我们的目的是研究职业性噪声暴露与动脉僵硬(AS)的关系，并进一步探讨microRNAs(MiRNAs)的调节作用。中国从湖北武汉的两家公司招聘了838名工人。通过职称噪声水平和工作年限评价累积职业噪声暴露水平。用示波仪测量的臂踝脉搏波速度(BaPWV)评估受试者的AS。CNE水平每增加1个单位，baPWV转换值增加0.002个单位(95%可信区间=0.001-0.003)。在特定性别的分析中，这种关联在男性中显著(β=0.002，95%CI=0.001-0.003)。同时，高暴露组双侧高频听力损失的风险显著高于非暴露组(OR=1.895，95%CI=1.024~3.508)，双侧高频听力损失患者的双侧耳声传播速度显著高于非暴露组(β=0.032，95%CI=0.003~0.061)。职业噪声暴露和AS与血浆miR-92a-3p和miR-21-5p均呈负相关，这两种miRNAs分别介导了职业噪声与AS关联的15.0%和16.8%(P
Long-term noise exposure is reported to damage cardiovascular system, but the relationship between occupational noise exposure and arterial stiffness (AS) and the underlying mechanism is still unclear. We aimed to investigate the association of occupational noise exposure with arterial stiffness (AS), and further explore the mediation roles of microRNAs (miRNAs). A total of 838 workers were recruited from two companies in Wuhan, Hubei, China. Cumulative occupational noise exposure (CNE) was assessed through noise level of job title and work years in occupational noise. The AS for the participants were evaluated using brachial-ankle pulse wave velocity (baPWV) measured by an oscillometric device. Each 1-unit increase in CNE levels was significantly associated with a 0.002 (95% confidence interval (CI)=0.001-0.003) unit increase in ln-transformed values of baPWV. In the sex-specific analysis, the association was significant in males (beta=0.002, 95%CI=0.001-0.003). Meanwhile, the risk of bilateral hearing loss at high frequency was significantly higher in the high-exposed group than non-exposed group (OR=1.895, 95%CI=1.024-3.508), and participants with bilateral hearing loss at high frequency had a significantly higher level of ln-transformed baPWV (beta=0.032, 95%CI=0.003-0.061). Occupational noise exposure and AS were both negatively associated with plasma miR-92a-3p and miR-21-5p, and the two miRNAs mediated 15.0% and 16.8% of the association of occupational noise with AS (P