Effect of Marijuana Use on Thyroid Function and Autoimmunity
Effect of Marijuana Use on Thyroid Function and Autoimmunity
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DOI：
10.1089/thy.2016.0197
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发表时间：
2017-02-01
期刊：
影响因子：
6.6
通讯作者：
Motaghedi, Roja
中科院分区：
文献类型：
--
作者：
Malhotra, Sonali;Heptulla, Rubina A.;Motaghedi, Roja
背景：医疗用途大麻在 24 个州合法化，娱乐用途在 5 个州合法化。然而，大麻使用对甲状腺功能和自身免疫的影响尚不清楚。方法：我们对 2007 年至 2012 年期间进行的国家健康和营养检查调查 (NHANES) 的数据进行了横断面分析，以评估大麻对吸食者甲状腺功能和自身免疫的影响。我们纳入了 5280 名年龄在 18 至 69 岁的成年人，他们回答了与大麻使用相关的问题，并提供了与甲状腺参数相关的实验室结果。主题被分类为非用户（从未使用过）、过去的用户（30 天前使用过）和最近的用户（过去 30 天内使用过）。使用 NHANES 甲状腺参数的标准临界值，我们将最近的使用者与非使用者和过去的使用者进行比较，并计算这些组中临床显着甲状腺功能障碍的相对发生率的比值比。然后进行多变量逻辑回归来控制混杂因素。结果：54% 的受试者报告终生使用大麻，其中 15% 最近使用过大麻。单变量回归分析显示，与非吸食者/过去吸食大麻的人相比，最近吸食大麻的人促甲状腺素（TSH）升高和抗甲状腺过氧化物酶抗体（TPOAb）阳性的频率显着降低。控制混杂因素后，最近吸食大麻仍然是 TSH 的独立预测因素
Background: Marijuana is legalized for medical use in 24 states and for recreational use in 5. However, effects of marijuana use on thyroid function and autoimmunity are unknown.Methods: We performed a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012 to assess the effects of marijuana on thyroid function and autoimmunity in users. We included 5280 adults ages 18 to 69 years, who responded to questions related to marijuana use and had laboratory results related to thyroid parameters. Subjects were categorized as nonusers (never used), past users (used prior to 30 days ago), and recent users (used within last 30 days). Using NHANES normative cut offs for thyroid parameters, we compared recent users with nonusers and past users and calculated the odds ratios for the relative rate of clinically significant thyroid dysfunction in those groups. Multivariate logistic regression was then performed to control for confounders.Results: Fifty-four percent of subjects reported lifetime cannabis use, with 15% using it recently. Univariate regression analysis showed that recent marijuana users had significantly lower frequency of elevated thyrotropin (TSH) and positive anti-thyroperoxidase antibody (TPOAb) versus nonusers/past users. After controlling for confounders, recent marijuana use remained an independent predictor for TSH