The sequelae of herpes zoster
The sequelae of herpes zoster
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DOI：
10.1001/archinte.157.11.1209
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发表时间：
1997-06-09
影响因子：
--
通讯作者：
Platt, R
中科院分区：
文献类型：
--
作者：
Galil, K;Choo, PW;Platt, R
背景：在过去的40年里，疱疹测试仪的发病率似乎有大幅增加。目的：确定疱疹测试仪并发症的风险在过去40年中是否发生了变化。方法：对一家卫生维护机构的自动化医疗记录进行筛选，以寻找建议疱疹测试仪的诊断代码和潜在的复杂的测试仪病例。带状疱疹诊断的预测值是从抽样全文记录中计算出来的。结果：在符合资格标准的859名疱疹病毒测试者中，101人至少经历了I级并发症，相当于60天的风险为12%。校正了并发症发现策略的敏感性，风险估计为14%。随着年龄的增长，风险显著增加，年龄大于的人发生并发症的风险是年龄小于25岁的人的6倍以上(优势比为8.3；95%可信区间为2.5-29.3)。皮疹的三叉神经分布和与免疫损害相关的某些条件的出现似乎增加了风险。结论：在以人群为基础的样本中，疱疹测试仪发病率的明显增加并没有伴随着特定或总体并发症风险的变化。高龄和其他与细胞免疫功能减弱相关的疾病可能会增加经历复杂带状疱疹病程的风险。
Background: The last 40 years was a period during which the incidence of herpes tester appears to have increased substantially.Objective: To determine whether the risk of complications of herpes tester has changed during the last 40 years.Methods: The automated medical records of a health maintenance organization were screened for diagnosis codes suggesting herpes tester and potentially complicated cases of tester. The predictive value of a herpes zoster diagnosis was calculated from sampling full-text records. Records of all patients with codes suggesting complications were reviewed in full.Results: Of 859 individuals with herpes tester who met the eligibility criteria, 101 were identified who experienced at least I complication, corresponding to a 60-day risk of 12%. Corrected for the sensitivity of the complication-finding strategy, the risk estimate was 14%. Risk increased markedly with age, with those older than 64 years having more than 6 times the risk of complications of those younger than 25 years (odds ratio, 8.3; 95% confidence interval, 2.5-29.3). Trigeminal distribution of rash and the presence of certain conditions associated with immune compromise appeared to increase risk.Conclusions: The apparent increase in the incidence of herpes tester was not accompanied by a change in the risk of specific or overall complications in a population-based sample. Advanced age and other conditions associated with waning cellular immunity may confer an increased risk of experiencing a complicated course of herpes zoster.