Data Resource Profile: Clinical Practice Research Datalink (CPRD).
Data Resource Profile: Clinical Practice Research Datalink (CPRD).
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DOI：
10.1093/ije/dyv098
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发表时间：
2015-06
影响因子：
7.7
通讯作者：
Smeeth L
中科院分区：
文献类型：
--
作者：
Herrett E;Gallagher AM;Bhaskaran K;Forbes H;Mathur R;van Staa T;Smeeth L
临床实践研究数据链（CPRD）是一个正在进行的全科医生匿名医疗记录的初级保健数据库，覆盖了来自英国674个实践的1130多万患者。有440万例符合质量标准的活跃（存活，目前注册）患者，约6.9%的英国人群被纳入，患者在年龄、性别和种族方面广泛代表英国一般人群。在英国，全科医生是初级保健和专家转诊的守门人。因此，《残疾人权利公约》初级保健数据库是供研究使用的丰富的卫生数据来源，包括人口统计、症状、检测、诊断、治疗、与健康有关的行为和转诊到二级保健的数据。对于超过一半的患者，与二级护理，疾病特定队列和死亡率记录的数据集的联系增加了可用于研究的数据范围。CPRD在国际上被广泛用于流行病学研究，并已被用于产生1000多项研究，发表在同行评审的期刊上，涉及广泛的健康结果。然而，研究人员必须意识到常规收集的电子健康记录的复杂性，包括管理变量完整性、错误分类和研究疾病定义的方法。
The Clinical Practice Research Datalink (CPRD) is an ongoing primary care database of anonymised medical records from general practitioners, with coverage of over 11.3 million patients from 674 practices in the UK. With 4.4 million active (alive, currently registered) patients meeting quality criteria, approximately 6.9% of the UK population are included and patients are broadly representative of the UK general population in terms of age, sex and ethnicity. General practitioners are the gatekeepers of primary care and specialist referrals in the UK. The CPRD primary care database is therefore a rich source of health data for research, including data on demographics, symptoms, tests, diagnoses, therapies, health-related behaviours and referrals to secondary care. For over half of patients, linkage with datasets from secondary care, disease-specific cohorts and mortality records enhance the range of data available for research. The CPRD is very widely used internationally for epidemiological research and has been used to produce over 1000 research studies, published in peer-reviewed journals across a broad range of health outcomes. However, researchers must be aware of the complexity of routinely collected electronic health records, including ways to manage variable completeness, misclassification and development of disease definitions for research.