Lethal outbreak of disease associated with feline calicivirus infection in cats
Lethal outbreak of disease associated with feline calicivirus infection in cats
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DOI：
10.1136/vr.158.16.544
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发表时间：
2006-04-22
影响因子：
2.2
通讯作者：
Radford, A. D.
中科院分区：
文献类型：
--
作者：
Coyne, K. P.;Jones, B. R. D.;Radford, A. D.
最近，在美国，猫杯状病毒（FCV）的毒性突变体已被鉴定为严重和急性毒性全身性疾病的原因，其特征在于猫群中的黄疸、水肿和高死亡率。FCV疾病的这种严重表现迄今仅在美国报告。然而，在2003年，疾病爆发影响了英国一个有四只成年猫和一只邻居家的成年猫的家庭。家中的三只成年猫和邻居猫出现临床体征，包括发热（39.5至40.5 ℃）、跛行、失声、食欲不振和黄疸。一只猫在极端情况下被安乐死，两只死亡，一只康复。其中一只猫的尸检显示右飞节和右肘关节周围有局灶性蜂窝织炎。对两只猫的选定器官进行组织病理学检查的主要发现是弥漫性肝细胞坏死伴轻度炎症浸润。免疫组织学鉴定FCV抗原的实质和枯否细胞在这两个动物的肝脏和肺泡巨噬细胞的其中之一。此外，通过电子显微镜在一只猫的肝细胞内观察到杯状病毒样颗粒。从两只死亡猫和两只存活猫中分离FCV。序列分析表明，它们都感染了相同的病毒株，但它不同于美国猫中与毒性全身性疾病相关的FCV株。通过在业主家中隔离，疫情得到成功控制。
Recently, in the USA, virulent mutants of feline calicivirus (FCV) have been identified as the cause of a severe and acute virulent systemic disease, characterised by jaundice, oedema and high mortality in groups of cats. This severe manifestation of FCV disease has so far only been reported in the USA. However, in 2003, an outbreak of disease affected a household of four adult cats and an adult cat from a neighbouring household in the UK. Three of the adult cats in the household and the neighbouring cat developed clinical signs including pyrexia (39.5 to 40.5 degrees C), lameness, voice loss, inappetence and jaundice. one cat was euthanased in extremis, two died and one recovered. A postmortem examination of one of the cats revealed focal cellulitis around the right hock and right elbow joints. The principal finding of histopathological examinations of selected organs from two of the cats was disseminated hepatocellular necrosis with mild inflammatory infiltration. Immunohistology identified FCV antigen in parenchymal and Kupffer cells in the liver of both animals and in alveolar macrophages of one of them. in addition, calicivirus-like particles were observed by electron microscopy within the hepatocytes of one cat. FCV was isolated from two of the dead cats and from the two surviving cats. Sequence analysis showed that they were all infected with the same strain of virus, but that it was different from strains of FCV associated with the virulent systemic disease in cats in the USA. The outbreak was successfully controlled by quarantine in the owner's house.