Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019.
Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019.
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全球痴呆症死亡率：2019 年全球疾病负担研究新方法的应用和结果。
DOI：
10.1002/trc2.12200
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
GBD 2019 Collaborators
中科院分区：
文献类型：
--
作者：
GBD 2019 Collaborators
痴呆症目前是全球死亡的主要原因之一，随着人口增长和人口老龄化的相应增加，痴呆症导致的死亡率在未来可能会增加。然而，随着时间的推移和国家之间，生命登记系统编码实践的巨大不一致性使全球痴呆症死亡率的估计复杂化。我们荟萃分析了痴呆症患者的超额死亡风险，并将这些估计值乘以严重终末期疾病患者中痴呆症死亡的比例，以计算可能归因于痴呆症的总死亡人数。我们估计，2019年全球有162万人（95%不确定区间[UI]: 0.41-4.21）死于痴呆症。女性痴呆症死亡人数（106万[0.27-2.71]）高于男性（56万[0.14-1.51]），这在很大程度上（但并非完全）是由于女性的预期寿命较高（年龄标准化的男女比例为1.19[1.10-1.26]）。由于人口老龄化，1990年至2019年期间，痴呆症的所有年龄段死亡率大幅增加（100.1%[89.1-117.5]）。2019年，与全球疾病负担（GBD）研究中估计的其他疾病导致的死亡相比，痴呆症导致的死亡在全球所有年龄段中排名第七，在70岁及以上人群中排名第四。痴呆症造成的死亡率是一个巨大的全球负担，随着全球老年人口的扩大，预计未来将继续增长。
Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. We meta‐analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end‐stage disease to calculate the total number of deaths that could be attributed to dementia. We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age‐standardized female‐to‐male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all‐age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.
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影响因子：
9.9
作者：
James, Bryan D.;Leurgans, Sue E.;Bennett, David A.
通讯作者：
Bennett, David A.
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
14
作者：
Lin, Pei-Jung;Fillit, Howard M.;Neumann, Peter J.
通讯作者：
Neumann, Peter J.
影响因子：
6.3
作者：
Beydoun, May A.;Beydoun, Hind A.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
14
作者：
Gauthier, Serge;Albert, Marilyn;Middleton, Lefkos T.
通讯作者：
Middleton, Lefkos T.