Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients
Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients
复制标题
DOI：
10.1016/j.jdiacomp.2014.03.003
复制
发表时间：
2014-09-01
影响因子：
3
通讯作者：
Murata, Toshinori
中科院分区：
文献类型：
--
作者：
Hirano, Takao;Iesato, Yasuhiro;Murata, Toshinori
目的：探讨皮肤自发荧光(AF)作为组织晚期糖基化终末产物(AGE)积聚的标志物及其与2型糖尿病(DM)患者糖尿病视网膜病变(DR)和糖尿病黄斑水肿(DME)的患病率及严重程度的关系。方法：选择138例2型DM患者，其中增殖型DR 31例，非增殖型DR 71例，非增殖型DR 36例，正常对照组111例。在测量皮肤AF和HbA1c的同时，还测定了DM的自我评估持续时间。根据国际标准对DR和DME分期进行分类。结果：与非DM对照组相比，DM患者的皮肤AF显著增加。此外，皮肤房颤与DR的严重程度相关，而单独测量HbA1c和自评DM病程则不相关。这3个因素均与DME的患病率或严重程度无关。结论：在2型DM患者中，皮肤AF水平可以在筛查的基础上无创地测量，而不需要皮肤活检或采血，比单独测量HbA1c或自评DM病程对DR的存在和严重程度具有更强的预测能力。(C)2014 Elsevier Inc.保留所有权利。
Aims: We evaluated skin autofluorescence (AF) as a marker of tissue advanced glycation end-product (AGE) accumulation and examined whether it was related to the prevalence and severity of diabetic retinopathy (DR) and of diabetic macular edema (DME) in patients with type 2 diabetes mellitus (DM).Methods: This study included 138 type 2 DM patients consisting of 31 patients with proliferative DR, 71 patients with non-proliferative DR, and 36 patients without retinopathy, in addition to 111 non-DM control subjects. At the time of skin AF and HbA1c measurement, self-assessed duration of DM was also determined. DR and DME stages were classified according to international guidelines.Results: Skin AF was significantly increased in patients with DM as compared with non-DM controls. Furthermore, skin AF was correlated with the severity of DR, whereas single measurement of HbA1c and self-assessed DM duration were not. None of these 3 factors showed a correlation with DME prevalence or severity.Conclusions: Skin AF levels, which can be measured non-invasively on a screening basis without skin biopsy or blood sampling, have a greater predictive ability for the presence and severity of DR than single measurement of HbA1c or self-assessed DM duration in patients with type 2 DM. (C) 2014 Elsevier Inc. All rights reserved.