Iron trafficking system in Helicobacter pylori
Iron trafficking system in Helicobacter pylori
复制标题
幽门螺杆菌中的铁运输系统
DOI：
10.1007/s10534-011-9512-8
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发表时间：
2012-04-01
期刊：
影响因子：
3.5
通讯作者：
Sun, Xuesong
中科院分区：
文献类型：
--
作者：
Ge, Ruiguang;Sun, Xuesong
幽门螺杆菌感染与消化性溃疡、胃恶性肿瘤和缺铁性贫血密切相关。铁对几乎所有生物都是必需的，因此研究铁的摄取和运输系统对了解幽门螺杆菌的病理作用是重要的。迄今为止，幽门螺杆菌的输铁系统尚不完全清楚，有待进一步研究。本文简要介绍了目前有关铁摄取和调控的信息，如铁运输中的FeoB、血红蛋白摄取中的FrpB2、血红素加工中的HugZ、转铁蛋白利用中的毒力因子（VacA和CagA）、铁储存中的Pfr和NapA以及铁调控中的Fur等。该铁转运系统的确定将有助于我们了解幽门螺杆菌在各种胃疾病和缺铁性贫血中的病理作用，并促进有效抗菌药物的进一步开发。
Helicobacter pylori infections are closely associated with peptic ulcers, gastric malignancy and iron deficiency anemia. Iron is essential for almost all living organisms and the investigation of iron uptake and trafficking system is thus important to understand the pathological roles of H. pylori. Up to now, the iron trafficking system of H. pylori is not yet fully clear and merits further efforts in this regards. The available information about iron uptake and regulation has been discussed in this concise review, such as FeoB in ferrous transportation, FrpB2 in hemoglobin uptake, HugZ in heme processing, virulence factors (VacA and CagA) in transferrin utilization, Pfr and NapA in iron storage and Fur in iron regulation. The identified iron trafficking system will help us to understand the pathological roles of H. pylori in the various gastric diseases and iron deficiency anemia and stimulates further development of effective anti-bacterial drugs.