The pathogenesis of the meningitis caused by Streptococcus suis:: the unresolved questions
The pathogenesis of the meningitis caused by Streptococcus suis:: the unresolved questions
复制标题
DOI：
10.1016/s0378-1135(00)00250-9
复制
发表时间：
2000-10-01
影响因子：
3.3
通讯作者：
Segura, M
中科院分区：
文献类型：
--
作者：
Gottschalk, M;Segura, M
猪链球菌（Streptococcus suis）是世界范围内最重要的猪病原菌之一。在所描述的血清型中，2型是最常与疾病相关的血清型。尽管近年来的研究越来越多，但对毒力因子和感染发病机制的认识仍然有限。本文综述了近年来国内外关于S.猪血清2型的毒力因子和由这一重要细菌物种引起的脑膜炎的发病机制。此外，还对感染的关键步骤，如细菌从粘膜表面侵入到血液中、细菌在血液中的存活、细菌从血液侵入中枢神经系统等提出了一些假说。最后，还讨论了动物免疫系统的刺激（炎症反应）在感染过程中的作用。一个完整的理解细胞相互作用的途径，S。猪流感病毒可能会跟随宿主体内的病毒，这可能会对疾病的进展提供重要的见解。进一步研究猪链球菌引起脑膜炎的机制将有助于开发潜在的治疗方法。猪传染病。(C)2000 Elsevier Science B.V.保留所有权利。
Streptococcus suis is one of the most important swine pathogens world-wide. Among the serotypes described, type 2 is the serotype most frequently associated with disease. Despite increasing research in recent years, knowledge of virulence factors and the pathogenesis of the infection remain limited. This review discusses the currently available information on S. suis serotype 2 virulence factors and the pathogenesis of the meningitis caused by this important bacterial species. In addition, some hypotheses on the critical steps of the infection, such as bacterial invasion from mucosal surfaces to the bloodstream, survival of bacteria in blood, and invasion from blood into the central nervous system, are presented, Finally, the role that the stimulation of the immune system of animals (inflammatory reaction) could play during infection is also discussed. A complete understanding of the cell-interacting pathways that S. suis may follow inside the host could give important insights into the progression of disease. Further studies to delineate the mechanisms through which S, suis induces meningitis will contribute to the development of potential therapies for S. suis infections. (C) 2000 Elsevier Science B.V. All rights reserved.