Parenteral nutrition effect on serum insulin in the preterm infant.
Parenteral nutrition effect on serum insulin in the preterm infant.
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肠外营养对早产儿血清胰岛素的影响。
DOI：
10.1542/peds.80.5.693
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发表时间：
1987
期刊：
影响因子：
8
通讯作者：
I. Hanning
中科院分区：
文献类型：
--
作者：
S. Andronikou;I. Hanning
测量了两组与胎龄匹配的早产儿的血糖和血清胰岛素水平。两组均在出生后72小时内接受非肠道喂养，并因呼吸窘迫综合征而接受机械通气。A组11例，静脉滴注10%葡萄糖5 mg/kg/min；B组12例，在静脉滴注10%葡萄糖的基础上加用氨基酸液1.2g/(kg·d)，输液速度与A组相同。开始输液24小时后，两组婴儿的血糖和血清胰岛素水平没有差异；然而，48小时时，接受氨基酸和葡萄糖输注的婴儿的胰岛素水平显著高于仅接受葡萄糖输注的婴儿(P<0.01)。两组患者血糖水平均保持稳定。我们的结论是，在稳定的早产儿中，持续氨基酸输注相关的较高胰岛素水平并不会导致低血糖。
Blood glucose and serum insulin levels were measured in two groups of preterm infants that had been matched for gestational age. Both groups were fed parenterally during the first 72 hours of life and were mechanically ventilated because of respiratory distress syndrome. Group A infants (n = 11) received 10% glucose (infusion rate 5 mg/kg/min) and group B infants (n = 12) received amino acid solution (1.2 g/kg/d) in addition to 10% glucose at the same rate as those in group A. Infants in both groups received 90 mL/kg of fluid per day. There was no difference in blood glucose or serum insulin levels between the two groups 24 hours after beginning the infusion; however, at 48 hours there was a significantly (P less than .01) higher insulin level in infants receiving amino acid and glucose infusion compared with those receiving only glucose. Blood glucose level remained stable in both groups. We conclude that, in the stable preterm infant, the higher insulin level associated with continuous amino acid infusion does not result in hypoglycemia.