Regulation of endochondral ossification by transcription factors
Regulation of endochondral ossification by transcription factors
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DOI：
10.2741/4076
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发表时间：
2012-06
期刊：
影响因子：
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通讯作者：
R. Nishimura;K. Hata;K. Ono;K. Amano;Yoko Takigawa;M. Wakabayashi;R. Takashima;T. Yoneda
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文献类型：
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作者：
R. Nishimura;K. Hata;K. Ono;K. Amano;Yoko Takigawa;M. Wakabayashi;R. Takashima;T. Yoneda
摘要软骨内骨化是一种非常独特而复杂的生物学过程，它与骨骼发育和组织配对密切相关。遗传学研究和基因靶向方法确定了几个转录因子在软骨内骨化中发挥重要作用。这些转录因子顺序地、协调地调节软骨内骨化的每一步，从而维持该程序的时空控制。重要的是，这些转录因子形成大的蛋白质复合物来控制软骨内骨化过程中的染色质重塑、组蛋白修饰、转录和剪接步骤。了解这些转录因子如何调节其靶基因的表达也很重要。生物化学和分子克隆技术在很大程度上有助于鉴定转录复合物的组分和靶基因。最近，内质网（ER）应激在软骨内骨化中的重要性已被报道。转录因子BBF2H7通过调节软骨形成基质的适当分泌而在软骨细胞中充当ER应力传感器。我们将讨论转录因子如何调节软骨内骨化。
Abstract Endochondral ossification is very unique and complex biological event which is associated with skeletal development and tissue partnering. Genetic studies and gene-targeting approaches identified several transcription factors that play important roles in endochondral ossification. These transcription factors sequentially and harmoniously regulate each step of endochondral ossification, and consequently maintain the spatio-temporal control of the program. Importantly, these transcription factors form large protein complex to control chromatin remodeling, histone modification, transcription and splicing steps during endochondral ossification. It is also important to understand how these transcription factors regulate expression of their target genes. Biochemical and molecular cloning techniques largely contributed to identification of the components of the transcriptional complex and the target genes. Most recently, importance of endoplasmic reticulum (ER) stress in endochondral ossification has been reported. A transcription factor, BBF2H7, functions as an ER stress sensor in chondrocytes through regulation of appropriate secretion of chondrogenic matrices. We would like to discuss how the transcription factors regulate endochondral ossification.