CLASSICAL-CONDITIONING OF THE RABBIT EYELID RESPONSE WITH A MOSSY-FIBER STIMULATION CS .1. PONTINE NUCLEI AND MIDDLE CEREBELLAR PEDUNCLE STIMULATION
CLASSICAL-CONDITIONING OF THE RABBIT EYELID RESPONSE WITH A MOSSY-FIBER STIMULATION CS .1. PONTINE NUCLEI AND MIDDLE CEREBELLAR PEDUNCLE STIMULATION
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DOI：
10.1037/0735-7044.100.6.878
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发表时间：
1986-12-01
影响因子：
1.9
通讯作者：
THOMPSON, RF
中科院分区：
文献类型：
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作者：
STEINMETZ, JE;ROSEN, DJ;THOMPSON, RF
以小脑苔藓纤维刺激为条件刺激(CS)，以空气喷雾为非条件刺激(US)，对18只兔的瞬膜/眼皮反应进行了经典的条件性刺激。桥脑背外侧核、外侧核、内侧核和小脑中脚是刺激CS训练的有效部位。在一组兔子中，配对试验产生了强健的条件眼皮反应，随后用单独的CS和明确不配对的CS和US来消除。在第二组兔子中，在未配对的CS和US演示的4天内，没有明显的条件性反应。然而，在配对训练开始后，条件性反应确实出现了。损毁小脑间位核完全消除了第三组过度使用苔藓纤维CS和喷气US的兔的条件性反应。这些结果支持了以前的研究，这些研究表明小脑在简单习得反应的获得和保持中起着关键作用。此外，目前的结果支持了先前关于小脑功能的理论，即苔藓纤维为小脑提供关键的“学习”输入，以获得和保持运动技能。
The nictitating membrane/eyelid responses of 18 rabbits were classically conditioned using cerebellar mossy-fiber stimulation as a conditioned stimulus (CS) and air puff as an unconditioned stimulus (US). The dorsolateral, lateral, and medial pontine nuclei and the middle cerebellar peduncle were effective stimulation-CS sites for training. In one group of rabbits, robust conditioned eyelid responses were produced with paired trials and subsequently extinguished with CS-alone and explicitly unpaired presentation of the CS and US. In a second group of rabbits, no conditioned responses were evident for 4 days of unpaired CS and US presentations. Conditioned responses did develop, however, after paired training was begun. Lesions of the interpositus nucleus of the cerebellum completely abolished the conditioned responses of a third group of rabbits overtrained with the mossy-fiber CS and air-puff US. These results support previous studies which have demonstrated that the cerebellum is critically involved in acquisition and retention of simple learned responses. In addition, the present results support previous theories of cerebellar function which have proposed that mossy fibers supply critical “learning” input to the cerebellum for acquisition and retention of motor skills.