Cytokine-Ion Channel Interactions in Pulmonary Inflammation.
Cytokine-Ion Channel Interactions in Pulmonary Inflammation.
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DOI：
10.3389/fimmu.2017.01644
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发表时间：
2017
影响因子：
7.3
通讯作者：
Stammberger U
中科院分区：
文献类型：
--
作者：
Hamacher J;Hadizamani Y;Borgmann M;Mohaupt M;Männel DN;Moehrlen U;Lucas R;Stammberger U
肺在概念上代表了一个海绵，它串联在身体的体循环中吸收氧气并消除二氧化碳。因此，肺泡上皮的巨大表面积与肺毛细血管相匹配。肺的持续暴露于外界需要一个有能力的免疫系统，临床免疫缺陷与肺部感染的关联证明了这一点。从子宫内到出生后和成人的情况下，无论是出生后，还是在流体静力或渗透性水肿的情况下，都有一种固有的至关重要的需要来控制肺泡液的再吸收。虽然关于离子通道和水孔对液体和溶质重吸收的生理基础已有大量文献，但对于微生物感染、急性肺损伤或急性呼吸窘迫综合征等病理情况，以及移植肺的肺再植反应等方面的知识尚不多见。这篇综述的目的是讨论肺泡液体清除在肺损伤模型的选择，因此特别关注细胞因子和介质调节离子通道。炎症的特点是复杂且可能依赖于时间的共同信号，相关细胞类型之间的相互作用，以及细胞死亡和屏障功能障碍，这些可能不是唯一决定临床表现的因素。因此，本综述旨在提供综合思考，并希望在未来的研究中促进未满足需求的揭示。
The lungs conceptually represent a sponge that is interposed in series in the bodies’ systemic circulation to take up oxygen and eliminate carbon dioxide. As such, it matches the huge surface areas of the alveolar epithelium to the pulmonary blood capillaries. The lung’s constant exposure to the exterior necessitates a competent immune system, as evidenced by the association of clinical immunodeficiencies with pulmonary infections. From the in utero to the postnatal and adult situation, there is an inherent vital need to manage alveolar fluid reabsorption, be it postnatally, or in case of hydrostatic or permeability edema. Whereas a wealth of literature exists on the physiological basis of fluid and solute reabsorption by ion channels and water pores, only sparse knowledge is available so far on pathological situations, such as in microbial infection, acute lung injury or acute respiratory distress syndrome, and in the pulmonary reimplantation response in transplanted lungs. The aim of this review is to discuss alveolar liquid clearance in a selection of lung injury models, thereby especially focusing on cytokines and mediators that modulate ion channels. Inflammation is characterized by complex and probably time-dependent co-signaling, interactions between the involved cell types, as well as by cell demise and barrier dysfunction, which may not uniquely determine a clinical picture. This review, therefore, aims to give integrative thoughts and wants to foster the unraveling of unmet needs in future research.
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影响因子：
26.1
作者：
Angoulvant, Francois;Bellettre, Xavier;Gajdos, Vincent
通讯作者：
Gajdos, Vincent
DOI：
10.1165/2009-0335oc
发表时间：
2011-01-01
影响因子：
6.4
作者：
Althaus, Mike;Pichl, Alexandra;Morty, Rory E.
通讯作者：
Morty, Rory E.
DOI：
10.1152/ajplung.00163.2014
发表时间：
2015-01-01
影响因子：
4.9
作者：
Astrand, Annika B. M.;Hemmerling, Martin;Tarran, Robert
通讯作者：
Tarran, Robert
影响因子：
4.3
作者：
Althaus M;Clauss WG;Fronius M
通讯作者：
Fronius M
影响因子：
7.3
作者：
Azzam ZS;Kinaneh S;Bahouth F;Ismael-Badarneh R;Khoury E;Abassi Z
通讯作者：
Abassi Z