Maternally influenced embryonic lethality: allele specific genetic rescue at a female fertility locus in Drosophila melanogaster.
Maternally influenced embryonic lethality: allele specific genetic rescue at a female fertility locus in Drosophila melanogaster.
复制标题
母系影响胚胎致死率：果蝇雌性生育位点的等位基因特异性遗传拯救。
DOI：
10.1139/g76-092
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
D. Nash
中科院分区：
文献类型：
--
作者：
P. Romans;R. Hodgetts;D. Nash
一个新的基因座mel（1）R1，对胚胎发育有母体效应，已被定位在果蝇X染色体上约0.5处，细胞学定位在2D6和3A1带之间。基因型突变胚胎死亡，如果产生的纯合子突变女性，但生存，如果产生的杂合子女性。已分离出两个突变等位基因。其中之一是遗传上可以挽救的：当纯合子突变雌性与突变雄性交配时，所有的胚胎都会死亡，但当这些雌性与正常雄性交配时，就会产生雌性后代。另一个等位基因是不可挽救的。遗传拯救在该位点是显性的，因为两个突变等位基因杂合的雌性在与正常雄性的杂交中产生雌性后代。
A new locus, mel(1)R1, with a maternal effect on embryonic development, has been mapped at about 0.5 on the X chromosome of Drosophila melanogaster and localized cytologically between bands 2D6 and 3A1. Genotypically mutant embryos die if produced by homozygous mutant females but survive if produced by heterozygous females. Two mutant alleles have been isolated. One of these is genetically rescuable: when homozygous mutant females are mated to mutant males, all the embryos die, but when these females are mated to normal males, female offspring are produced. The other allele is not rescuable. Genetic rescue is dominant at this locus since females heterozygous for the two mutant alleles produce female offspring in crosses to normal males.